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. 2020 Oct 30;15(10):e0240751.
doi: 10.1371/journal.pone.0240751. eCollection 2020.

Effect of blood analysis and immune function on the prognosis of patients with COVID-19

Yue-Qiang Fu  1   2   3   4 , Yue-Lin Sun  1   3   4 , Si-Wei Lu  1   3   4 , Yang Yang  5 , Yi Wang  1   2   3   4 , Feng Xu  1   3   4
Affiliations

Effect of blood analysis and immune function on the prognosis of patients with COVID-19

Yue-Qiang Fu et al. PLoS One. .

Abstract

Introduction: This retrospective study investigated the implications of changes in blood parameters and cellular immune function in patients with Coronavirus Disease 2019 (COVID-19).

Methods: Records were reviewed of 85 patients admitted with COVID-19 between February 4 and 16, 2020. The primary outcome was in-hospital death.

Results: Fourteen patients died. The baseline leukocyte count, neutrophil count and hemoglobin was significantly higher in non-survivors compared with survivors, while the reverse was true of lymphocyte count, platelet, PaO2/FiO2, CD3+ count and CD4+ count. The percentage of neutrophil count > 6.3×109/L in death group was significantly higher than that in survival group, and multivariate logistic regression showed neutrophil count > 6.3×109/L was independently associated with mortality. However, there were not significant difference in IgG, IgM, IgA, C3, C4 and the percentage of IgE > 100 IU/ml between the death group and survival group. Areas under the receiver operating characteristic curves of the following at baseline could significantly predict mortality: leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts.

Conclusions: For hospitalized patients with COVID-19, lymphocyte, CD3+ and CD4+ counts that marked decrease suggest a poor outcome. Admission neutrophil count > 6.3 ×109/L is independently associated with mortality. At admission, leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts should receive added attention.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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