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. 2021 May;62(2):e162-e169.
doi: 10.1111/ajd.13491. Epub 2020 Oct 30.

Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases

Arturo Bonometti  1 , Jessica Gliozzo  2   3 , Chiara Moltrasio  2 , Filippo Bagnoli  4 , Emilio Berti  2   5
Affiliations

Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases

Arturo Bonometti et al. Australas J Dermatol. 2021 May.

Abstract

Background: Histiocytoses are haematological disorders of bone marrow origin that share many biological and clinical features with haematological neoplasms. The association between histiocytoses of the cutaneous-group and myeloid malignancies is a poorly investigated topic of high biological and clinical impact.

Methods: We performed a systematic review of the scientific literature, compliant with PRISMA guidelines, to unravel the clinical and pathological features of this intriguing association.

Findings: We gathered and analysed 102 patients. Most were children with generalised cutaneous eruptions and displayed risk organ involvement (i.e. bone marrow, spleen, liver). Interestingly, all these features are uncommonly encountered in C-group histiocytosis not associated with haematological neoplasms.

Conclusions: Our review shows that generalised eruptions and risk organ involvement in cutaneous-group histiocytosis should raise a suspicion for a concomitant myeloid neoplasm both in children and in adults and warrant further investigations. A rapid recognition of this association is required to start a prompt and effective therapeutic management given the aggressive behaviour of the associated myeloid neoplasm in most instances.

Keywords: association; histiocytoses; leukaemia cutis; myeloid neoplasms; systematic review.

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