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Review
. 2020 Dec;97(12):1217-1221.
doi: 10.1002/cyto.a.24249. Epub 2020 Nov 4.

Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review

Ihsane Benlyamani  1   2 , Fabienne Venet  1   2 , Rémy Coudereau  1   2 , Morgane Gossez  1   2 , Guillaume Monneret  1   2
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Free article
Review

Monocyte HLA-DR Measurement by Flow Cytometry in COVID-19 Patients: An Interim Review

Ihsane Benlyamani et al. Cytometry A. 2020 Dec.
Free article

Abstract

Several months after the sudden emergence of SARS-CoV-2 and COVID-19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID-19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis-induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA-DR molecules on circulating monocytes (mHLA-DR). In this interim review, we summarize the first mHLA-DR results in COVID-19 patients. In critically ill patients, results homogenously indicate a decreased mHLA-DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry.

Keywords: COVID-19; HLA-DR; flow cytometry; sepsis.

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