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Review
. 2020 Dec:255:124-128.
doi: 10.1016/j.ejogrb.2020.10.035. Epub 2020 Oct 16.

Changes in physiology and immune system during pregnancy and coronavirus infection: A review

Miaomiao Chen  1 , Jing Zeng  2 , Xiyao Liu  2 , Guoqiang Sun  3 , Ying Gao  3 , Jiujiang Liao  2 , Jiaxiao Yu  2 , Xin Luo  4 , Hongbo Qi  5
Affiliations
Review

Changes in physiology and immune system during pregnancy and coronavirus infection: A review

Miaomiao Chen et al. Eur J Obstet Gynecol Reprod Biol. 2020 Dec.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the 3rd epidemic coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Since December 2019, the outbreak of the Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 has aroused great attention around the world. Pregnant women and their fetuses have been concerned as a high-risk population. We explained why pregnant women are susceptible to coronavirus in terms of their adaptive changes in physiology and immune system during pregnancy, and described the associations between maternal clinical symptoms, perinatal outcomes and coronavirus infections.

Keywords: Coronavirus; Immune; Obstetric adverse outcome; Physiology; Pregnancy.

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Conflict of interest statement

Declaration of Competing Interest The authors report no declarations of interest.

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