. 2021 Jan:146:106219.

doi: 10.1016/j.envint.2020.106219. Epub 2020 Oct 27.

Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood

Ingrid Nordeide Kuiper¹, Cecilie Svanes², Iana Markevych³, Simone Accordini⁴, Randi J Bertelsen⁵, Lennart Bråbäck⁶, Jesper Heile Christensen⁷, Bertil Forsberg⁷, Thomas Halvorsen⁸, Joachim Heinrich⁹, Ole Hertel¹⁰, Gerard Hoek¹¹, Mathias Holm¹², Kees de Hoogh¹³, Christer Janson¹⁴, Andrei Malinovschi¹⁵, Alessandro Marcon⁴, Roy Miodini Nilsen¹⁶, Torben Sigsgaard¹⁷, Ane Johannessen¹⁸

Affiliations

¹ Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Electronic address: ingrid.nordeide.kuiper@helse-bergen.no.
² Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
³ Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany; Institute of Psychology, Jagiellonian University, Krakow, Poland; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
⁴ Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
⁵ Department of Clinical Science, University of Bergen, Bergen, Norway; Oral Health Centre of Expertise in Western Norway, Bergen, Norway.
⁶ Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
⁷ Department of Environmental Science, Aarhus University, Denmark.
⁸ Department of Clinical Science, University of Bergen, Bergen, Norway.
⁹ Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
¹⁰ Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
¹¹ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
¹² Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹³ Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
¹⁴ Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁵ Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
¹⁶ Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway.
¹⁷ Section of Environment, Occupation & Health, Institute of Public Health, Aarhus University, Aarhus Denmark.
¹⁸ Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

PMID: 33126061
DOI: 10.1016/j.envint.2020.106219

Free article

Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood

Ingrid Nordeide Kuiper et al. Environ Int. 2021 Jan.

Free article

. 2021 Jan:146:106219.

doi: 10.1016/j.envint.2020.106219. Epub 2020 Oct 27.

Authors

Affiliations

¹ Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Electronic address: ingrid.nordeide.kuiper@helse-bergen.no.
² Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
³ Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany; Institute of Psychology, Jagiellonian University, Krakow, Poland; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
⁴ Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
⁵ Department of Clinical Science, University of Bergen, Bergen, Norway; Oral Health Centre of Expertise in Western Norway, Bergen, Norway.
⁶ Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
⁷ Department of Environmental Science, Aarhus University, Denmark.
⁸ Department of Clinical Science, University of Bergen, Bergen, Norway.
⁹ Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
¹⁰ Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
¹¹ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
¹² Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹³ Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
¹⁴ Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁵ Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
¹⁶ Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway.
¹⁷ Section of Environment, Occupation & Health, Institute of Public Health, Aarhus University, Aarhus Denmark.
¹⁸ Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

PMID: 33126061
DOI: 10.1016/j.envint.2020.106219

Abstract

Objectives: To investigate if air pollution and greenness exposure from birth till adulthood affects adult asthma, rhinitis and lung function.

Methods: We analysed data from 3428 participants (mean age 28) in the RHINESSA study in Norway and Sweden. Individual mean annual residential exposures to nitrogen dioxide (NO₂), particulate matter (PM₁₀ and PM_2.5), black carbon (BC), ozone (O₃) and greenness (normalized difference vegetation index (NDVI)) were averaged across susceptibility windows (0-10 years, 10-18 years, lifetime, adulthood (year before study participation)) and analysed in relation to physician diagnosed asthma (ever/allergic/non-allergic), asthma attack last 12 months, current rhinitis and low lung function (lower limit of normal (LLN), z-scores of forced expiratory volume in one second (FEV₁), forced vital capacity (FVC) and FEV₁/FVC below 1.64). We performed logistic regression for asthma attack, rhinitis and LLN lung function (clustered with family and study centre), and conditional logistic regression with a matched case-control design for ever/allergic/non-allergic asthma. Multivariable models were adjusted for parental asthma and education.

Results: Childhood, adolescence and adult exposure to NO₂, PM₁₀ and O₃ were associated with an increased risk of asthma attacks (ORs between 1.29 and 2.25), but not with physician diagnosed asthma. For rhinitis, adulthood exposures seemed to be most important. Childhood and adolescence exposures to PM_2.5 and O₃ were associated with lower lung function, in particular FEV₁ (range ORs 2.65 to 4.21). No associations between NDVI and asthma or rhinitis were revealed, but increased NDVI was associated with lower FEV₁ and FVC in all susceptibility windows (range ORs 1.39 to 1.74).

Conclusions: Air pollution exposures in childhood, adolescence and adulthood were associated with increased risk of asthma attacks, rhinitis and low lung function in adulthood. Greenness was not associated with asthma or rhinitis, but was a risk factor for low lung function.

Keywords: Air pollution; Asthma; Greenness; Lung function; Rhinitis.

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Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood

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Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood

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