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Comparative Study
. 2020 Oct 30;99(44):e22701.
doi: 10.1097/MD.0000000000022701.

Clinical effects of transforaminal approach vs interlaminar approach in treating lumbar disc herniation: A clinical study protocol

Wei Chen  1 , Yong Zheng  2 , Guiqing Liang  1 , Guangfu Chen  3 , Yabin Hu  4
Affiliations
Comparative Study

Clinical effects of transforaminal approach vs interlaminar approach in treating lumbar disc herniation: A clinical study protocol

Wei Chen et al. Medicine (Baltimore). .

Expression of concern in

  • Expression of Concern: Study Protocols.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2025 Nov 7;104(45):e46330. doi: 10.1097/MD.0000000000046330. Medicine (Baltimore). 2025. PMID: 41204616 Free PMC article. No abstract available.

Abstract

Background: Percutaneous endoscopic lumbar discectomy (PELD) has routinely performed in recent years for lumbar disc herniation because of the advances in technology of minimally invasive spine surgery. Two common operating routes for PELD have been introduced in the literature: transforaminal approach (TA) and interlaminar approach (IA). The purpose of our current retrospective clinical trial was to study whether the effect of IA-PELD is better than TA-PELD in the incidence of complications and clinical prognosis scores in the patients with L5-S1 lumbar disc herniation.

Methods: Our present research was approved by the institutional review board in the Second Hospital of Nanjing. All the patients offered the informed consent. All the procedures containing human participants were conducted on the basis of the Helsinki Declaration. A retrospective analysis was implemented on 126 patients with L5-S1 disc herniated radiculopathy from March 2016 to March 2018, who were treated with the PELD utilizing the IA technique or the TA technique. Relevant data, such as the patients demographics, surgical duration, length of hospital stay, hospitalization expenses, complications were recorded. In our work, the outcomes of patients were determined at baseline, 6 months, 12 months, and 24 months after treatment. The measure of primary outcome was Oswestry Disability Index score. The other outcomes measured were Numeric Rating Scale pain scale, surgical duration, length of hospital stay, and complications. The software of SPSS Version 22.0 (IBM Corporation, Armonk, NY) was applied for the analysis of all the statistical data. When P value <.05, it was considered to be significant in statistics.

Results: This protocol will provide a solid theoretical basis for exploring which PELD approach is better in treatment of lumbar disc herniation.

Trial registration: This study protocol was registered in Research Registry (researchregistry5988).

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Song H, Hu W, Liu Z, et al. Percutaneous endoscopic interlaminar discectomy of L5-S1 disc herniation: a comparison between intermittent endoscopy technique and full endoscopy technique. J Orthop Surg Res 2017;12:162. - PMC - PubMed
    1. Chen J, Jing X, Li C, et al. Percutaneous endoscopic lumbar discectomy for l5s1 lumbar disc herniation using a transforaminal approach versus an interlaminar approach: a systematic review and meta-analysis. World Neurosurg 2018;116:412–20. - PubMed
    1. Chen Y, Wang JX, Sun B, et al. Percutaneous endoscopic lumbar discectomy in treating calcified lumbar intervertebral disc herniation. World Neurosurg 2019;122:1449–56. - PubMed
    1. Xu J, Li Y, Wang B, et al. Percutaneous endoscopic lumbar discectomy for lumbar disc herniation with modic changes via a transforaminal approach: a retrospective study. Pain Physician 2019;22:E601–8. - PubMed
    1. Li Y, Wang B, Wang S, et al. Full-endoscopic decompression for lumbar lateral recess stenosis via an interlaminar approach versus a transforaminal approach. World Neurosurg 2019;128:e632–8. - PubMed

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