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Meta-Analysis
. 2020 Oct 30;20(1):657.
doi: 10.1186/s12884-020-03346-4.

Effect of HELLP syndrome on acute kidney injury in pregnancy and pregnancy outcomes: a systematic review and meta-analysis

Qiang Liu  1 , Guan-Jun Ling  2 , Shao-Quan Zhang  2 , Wen-Qing Zhai  2 , Yi-Juan Chen  2
Affiliations
Meta-Analysis

Effect of HELLP syndrome on acute kidney injury in pregnancy and pregnancy outcomes: a systematic review and meta-analysis

Qiang Liu et al. BMC Pregnancy Childbirth. .

Abstract

Background: HELLP syndrome may increase adverse pregnancy outcomes, though the incidence of it is not high. At present, the impact of HELLP syndrome on P-AKI (acute kidney injury during pregnancy) and maternal and infant outcomes is controversial. Thus, we conducted a meta-analysis to find out more about the relationship between HELLP syndrome and P-AKI and pregnancy outcomes.

Methods: We systematically searched PubMed, Embassy and Cochrane Databases for cohort studies and RCT to assess the effect of HELLP syndrome on P-AKI and maternal and infant outcomes. Study-specific risk estimates were combined by using fixed-effect or random-effect models.

Results: This meta-analysis included 11 cohort studies with a total of 6333 Participants, including 355 cases of pregnant women with HELLP syndrome and 5979 cases that without. HELLP syndrome was associated with relatively higher risk of P-AKI (OR4.87 95% CI 3.31 ~ 7.17, P<0.001), fetal mortality (OR1.56 95% CI 1.45 ~ 2.11, P<0.001) and Maternal death (OR3.70 95% CI 1.72 ~ 7.99, P<0.001).

Conclusions: HELLP syndrome is associated with relatively higher risk of P-AKI, fetal mortality and maternal death.

Keywords: AKI; Acute kidney injury; HELLP syndrome; Pregnancy outcomes.

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Conflict of interest statement

Not applicable.

Figures

Fig. 1
Fig. 1
Process for identifying studies eligible for the meta-analysis
Fig. 2
Fig. 2
Comparison of the incidence of AKI in pregnant women with HELLP syndrome and no HELLP syndrome
Fig. 3
Fig. 3
Comparison of the Maternal death in pregnant women with HELLP syndrome and no HELLP syndrome
Fig. 4
Fig. 4
Comparison of the stillbirth in pregnant women with HELLP syndrome and no HELLP syndrome
Fig. 5
Fig. 5
Comparison of Neonatal death in pregnant women with HELLP syndrome and no HELLP syndrome
Fig. 6
Fig. 6
Begg’s test about Fig. 2
See this image and copyright information in PMC

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