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Comment
. 2020 Nov;98(5):1079-1081.
doi: 10.1016/j.kint.2020.08.004.

The transcriptomic signature of the aging podocyte

Dhanunjay Mukhi  1 , Katalin Susztak  2
Affiliations
Comment

The transcriptomic signature of the aging podocyte

Dhanunjay Mukhi et al. Kidney Int. 2020 Nov.

Abstract

Aging is the strongest independent risk factor for chronic kidney disease. Glomerular epithelial cells are unable to proliferate and have limited ability to renew; therefore, podocytes must maintain a delicate intracellular homeostasis that enables them to function and adapt to stress endured during the human life span. Here, Wang et al. performed unbiased transcriptomic analysis of aging podocytes and identified important novel regulators.

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Conflict of interest statement

DISCLOSURE

KS serves on the scientific advisory board of Jnana Therapeutics. The other author declared no competing interests.

Figures

Figure 1
Figure 1. Podocyte transcriptomic profiling was performed in young and aged podocytes.
Expression of genes associated with development metabolism and endocytosis was lower in aged mice. Expression of genes associated with inflammation, apoptosis, and p53 and mTOR was higher. Aging-associated signature genes were regulated by the transcription factor Grainyhead 2 (Grhl2). FACS, fluorescent activated cell sorter; VIPER, virtual inference of protein activity by enriched regulon.
See this image and copyright information in PMC

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