Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun;17(3):739-747.
doi: 10.1007/s12015-020-10070-1. Epub 2020 Oct 30.

Extracellular Matrix Remodeling and Development of Cancer

Koyeli Girigoswami  1 , Devender Saini  2 , Agnishwar Girigoswami  3
Affiliations
Review

Extracellular Matrix Remodeling and Development of Cancer

Koyeli Girigoswami et al. Stem Cell Rev Rep. 2021 Jun.

Abstract

The importance of stem cell growth and its fate is highly essential for the use of stem cells in therapy and regeneration. There are conflicting evidences regarding the actual role of stem cells when injected into a patient towards damage recovery and its lifespan inside the body. Tumor microenvironment differs from that of normal cells and may have a role in the growth of stem cells when associated with them. In cancer, the uncontrolled growth of cells remodels the extracellular matrix (ECM). The ECM alteration occurs as the mutated fibroblast cells release growth factors into the ECM which further alters the ECM directly or changes the epithelial cells and then alters the ECM. In this review we will discuss about the components and functions of ECM and how does it differ in cancer cells compared to normal cells. Abnormal dynamics of the ECM and its role in cancer progression will also be discussed. Graphical abstract.

Keywords: Cancer ECM; Cancer niche; ECM remodeling; Extracellular matrix; Stiffness of ECM.

PubMed Disclaimer

References

    1. Michel, G., Tonon, T., Scornet, D., Cock, J. M., & Kloareg, B. (2010). The cell wall polysaccharide metabolism of the brown alga Ectocarpussiliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes. New Phytologist, 188(1), 82–97.
    1. Alberts, B. (2002). Molecular biology of the cell ((4th Eds)). New York: Garland Science.
    1. Abedin, M., & King, N. (2010). Diverse evolutionary paths to cell adhesion. Trends in Cell Biology, 20(12), 734–742. - PubMed - PMC
    1. Kumar, V., Abbas, A. K., & Aster, J. C. (2015). Robbins and cotran pathologic basis of disease. Philadelphia: Elsevier Saunders.
    1. Alberts, B., Bray, D., Hopkin, K., Johnson, A., Lewis, J., Raff, M., et al. (2013). Essential cell biology. New York: Garland Science.

Publication types

LinkOut - more resources