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. 2021 Feb;106(2):241-249.
doi: 10.1111/ejh.13542. Epub 2020 Nov 17.

Comorbidity profile of adult survivors at 20 years following allogeneic hematopoietic cell transplantation

Ayesh K Seneviratne  1 , Clare Wright  1 , Wilson Lam  1 , Jeffrey H Lipton  1 , Fotios V Michelis  1
Affiliations

Comorbidity profile of adult survivors at 20 years following allogeneic hematopoietic cell transplantation

Ayesh K Seneviratne et al. Eur J Haematol. 2021 Feb.

Abstract

Numerous chronic medical conditions and complications can arise following allogeneic hematopoietic cell transplantation (HCT) that may have a negative impact on survival and quality of life.

Objective: The purpose of the present study was to review the comorbidities of a single-center cohort of allogeneic HCT recipients that survived 20 years postallogeneic transplantation.

Methods: We retrospectively investigated 172 patients that underwent allogeneic HCT at the Princess Margaret Cancer Centre between 1979 and 1998 and who survived at least 20 years post-HCT.

Results: The most frequent individual comorbidities documented were dyslipidemia (29%), hypertension (31%), osteoporosis (15%), hypothyroidism (15%), and depression/anxiety (13%). Follow-up data following the 20-year mark were available for 135 patients, overall survival (OS) of that group at 5 and 10 years was 94% and 90%, respectively. When grouped by the number of concurrent comorbidities, there was a significant difference in OS between the groups with 0-1, 2-3, and ≥4 comorbidities (P = .01).

Conclusions: Evidently, long-term allogeneic HCT recipients may develop a number of comorbidities that negatively influence survival even past the 20-year post-transplant mark. These findings warrant the continuous long-term medical follow-up of allogeneic transplant patients, regardless of age or time that has lapsed post-HCT.

Keywords: allogeneic HCT; comorbidities; long-term follow-up; survivorship.

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