Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 25;183(5):1143-1146.
doi: 10.1016/j.cell.2020.10.032. Epub 2020 Oct 30.

A Blueprint for Characterizing Senescence

Ananda L Roy  1 , Felipe Sierra  2 , Kevin Howcroft  3 , Dinah S Singer  3 , Norman Sharpless  3 , Richard J Hodes  2 , Elizabeth L Wilder  4 , James M Anderson  5
Affiliations

A Blueprint for Characterizing Senescence

Ananda L Roy et al. Cell. .

Abstract

Given the heterogeneity of senescent cells, our knowledge of both the drivers and consequences of cellular senescence in tissues and organs remains limited, as is our understanding of how this process could be harnessed for human health. Here we identified five broad areas that would help propel the field forward.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Five Broad Objectives to Help Build a Comprehensive Blueprint of Senescent Cells in Human Tissues and Organs
These five objectives are building a multimodal and multidimensional senescent cell atlas (Atlas); identifying a panel of reliable biomarkers (Biomarkers); imaging and visualizing (Imaging & visualization), including artificial intelligence tools to identify senescent cells; establishing experimental model systems (Model systems); and validation experiments (Perturbation & validation) via perturbation to test predictive models.
See this image and copyright information in PMC

References

    1. Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, et al. (2020). Senolytic CAR T cells reverse senescence-associated pathologies. Nature 583, 127–132. - PMC - PubMed
    1. Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, and Verdin E (2019). From discoveries in ageing research to therapeutics for healthy ageing. Nature 571, 183–192. - PMC - PubMed
    1. Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, and van Deursen JM (2017). Senescent cells: an emerging target for diseases of ageing. Nat. Rev. Drug Discov. 16, 718–735. - PMC - PubMed
    1. Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, et al. (2019). Cellular Senescence: Defining a Path Forward. Cell 179, 813–827. - PubMed
    1. Grosse L, Wagner N, Emelyanov A, Molina C, Lacas-Gervais S, Wagner KD, and Bulavin DV (2020). Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 32, 87–99.e6. - PubMed

LinkOut - more resources