Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review

Abstract

The rise of drug-resistance has made the deserted clinical requirement to improve of new classes of antibiotics agents. The development of antibacterial agents with the novel method of activity stays a high need worldwide. The treatment of bacterial infections remains a test in light of developing irresistible sicknesses and the expanding number of multidrug-resistance microbial pathogens. Therefore, there is a need for powerful activities to think of new successful therapeutic agents, and it is dire to find novel synthetic analogs against bacterial targets. The improvements of new, less harmful, minimum side-effort, and extremely dynamic sulfonyl or sulfonamide-bearing analogs are hot research topics in medicinal chemistry. This present review summarizes the current innovations of sulfonyl or sulfonamide-based derivatives with potential antibacterial activities against various Gram-positive and Gram-negative bacterial strains and discussing its various aspects of structure-activity relationship (SAR).

Keywords: Antibacterial activities; Pathogens; SAR; Sulfonamides; Sulfonyl (S(VI)).