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. 1987 Sep;22(9):669-71.
doi: 10.1007/BF02533948.

Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats

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Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats

T Chikai et al. Lipids. 1987 Sep.

Abstract

Fecal bile acids in germ-free rats were analyzed after inoculation with Bacteroides vulgatus, Bifidobacterium longum, Escherichia coli or Clostridium ramosum. B. vulgatus preferentially deconjugated tauro-beta-muricholic acid and B. longum taurocholic acid. C. ramosum deconjugated both bile acids, but E. coli deconjugated neither. 7 alpha-Dehydroxylation of bile acids was negligible even after 18 days of inoculation, but a small amount of 7-oxo-bile acids, less than 5%, was formed. Fecal excretion of bile acids increased after inoculation with B. vulgatus, B. longum and C. ramosum, but not with E. coli.

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