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. 1987 Aug;7(8):2968-73.
doi: 10.1128/mcb.7.8.2968-2973.1987.

Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum

R B Saint  1 , R L Coppel, A F Cowman, G V Brown, P T Shi, N Barzaga, D J Kemp, R F Anders
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Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum

R B Saint et al. Mol Cell Biol. 1987 Aug.

Abstract

The S antigens from different isolates of Plasmodium falciparum exhibit extensive size, charge, and serological diversity. We show here that the S-antigen genes behave as multiple alleles of a single locus. The size heterogeneity results from different numbers, lengths, and/or sequences of tandem repeat units encoded within the S-antigen genes. Two genes studied here encode antigenically different S antigens but nevertheless have closely related tandem repeat sequences. We show that antigenic differences can arise because repeats are translated in different reading frames.

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