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Review
. 2020 Oct 31;13(10):e239210.
doi: 10.1136/bcr-2020-239210.

Use of remdesivir in the presence of elevated LFTs for the treatment of severe COVID-19 infection

Andrew J Sabers  1 , Amber L Williams  1 , T Michael Farley  2   3
Affiliations
Review

Use of remdesivir in the presence of elevated LFTs for the treatment of severe COVID-19 infection

Andrew J Sabers et al. BMJ Case Rep. .

Abstract

An 82-year-old man with an extensive medical history presented to the emergency room with complaints of generalised weakness and cough. He tested positive for COVID-19 10 days prior to presenting to the emergency room. Although his symptoms started a week prior to diagnosis, his weakness increased, warranting emergency response. A comprehensive metabolic panel was drawn from the patient on admission, indicating markedly high liver function tests (LFTs) ≥20 times above the upper limit of normal. On day 1 of admission, the decision was still made to start remdesivir (5-day course) due to decompensated acute respiratory failure as well as dexamethasone. The patient's LFTs significantly improved throughout his hospital stay. The patient made a full recovery and was discharged on day 10 of hospitalisation.

Keywords: adult intensive care; drugs: infectious diseases; infections.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Daily remdesivir dose, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels during the hospital course.
See this image and copyright information in PMC

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MeSH terms