USE OF OPTICAL COHERENCE TOMOGRAPHY IN DETECTION OF CYSTOID MACULAR EDEMA AFTER TREATMENT WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

Abstract

The aim of the study was to determine the correlation between implanted IOL material type to detect CME after NSAID use in cataract surgery. Study involved 94 eyes of 72 patients. Eyes were equally divided into two groups (n-47 in each). Post-operatively treatment regimen for participants from Group I included antibiotic and NSAID eye drops, while participants from group II were treated only with antibiotic eye drops. Acrylic hydrophobic intraocular lens (IOL) was implanted in all patients comprising both groups. No patient developed cystoid macular edema from either group (CME). In both groups (with or without NSAID eye drops cover) mean central retinal thickness (CRT) was 230±0.005 microns before the surgery. No statistically significant changes of CRT was noted in both groups (5± 0.09 microns ) (p<0.5). Study analysis has shown, that cystoid macular edema has not developed in patients, who underwent uncomplicated cataract surgery with hydrophobic IOL implantation, with or without NSAID eye drop cover. There was no statistically and clinically significant difference between the groups in terms of CRT. Implantation of acrylic hydrophobic intraocular lens(IOL) has shown to provide high uveal biocompatibility. Major risk factors of CME in cataract surgery are intraoperative surgical complications. Certain systemic and local ophthalmic diseases, as well as topical use of prostaglandin analogs are also strongly linked to postoperative CME development. In conclusion, usage of NSAID eye drops in combination with antibiotic regimen in eyes undergoing cataract surgery, showed to have a beneficial effect on prevention of postoperative CME.