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. 2021 Jun;184(6):1059-1067.
doi: 10.1111/bjd.19644. Epub 2020 Nov 29.

Epidemiological changes in cutaneous lymphomas: an analysis of 8593 patients from the French Cutaneous Lymphoma Registry

G Dobos  1   2   3 , A de Masson  1   2   3 , C Ram-Wolff  1   2   3 , M Beylot-Barry  4 , A Pham-Ledard  4 , N Ortonne  5 , S Ingen-Housz-Oro  6 , M Battistella  2   3   7 , M d'Incan  8 , J Rouanet  9 , F Franck  9 , M D Vignon-Pennamen  7 , N Franck  10 , A Carlotti  11 , S Boulinguez  12 , L Lamant  13 , T Petrella  14 , S Dalac  15 , P Joly  16 , P Courville  17 , J Rivet  4   5 , O Dereure  18 , F Amatore  19 , S Taix  20 , F Grange  21 , A Durlach  22 , G Quéreux  23 , N Josselin  24 , I Moulonguet  1 , L Mortier  25 , R Dubois  26 , E Maubec  27 , L Laroche  27 , L Michel  2   3 , I Templier  28 , S Barete  29 , C Nardin  30 , O Augereau  31 , B Vergier  31 , M Bagot  1   2   3 ; French Study Group on Cutaneous Lymphomas (GFELC)
Affiliations

Epidemiological changes in cutaneous lymphomas: an analysis of 8593 patients from the French Cutaneous Lymphoma Registry

G Dobos et al. Br J Dermatol. 2021 Jun.

Abstract

Background: Primary cutaneous lymphomas (PCLs) are a heterogeneous group of T-cell (CTCL) and B-cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe and about potential changes over time.

Objectives: The aim of this retrospective study was to analyse the frequency of PCLs in the French Cutaneous Lymphoma Registry (GFELC) and to describe the demography of patients.

Methods: Patients with a centrally validated diagnosis of primary PCL, diagnosed between 2005 and 2019, were included.

Results: The calculated incidence was unprecedently high at 1·06 per 100 000 person-years. The number of included patients increased yearly. Most PCL subtypes were more frequent in male patients, diagnosed at a median age of 60 years. The relative frequency of rare CTCL remained stable, the proportion of classical mycosis fungoides (MF) decreased, and the frequency of its variants (e.g. folliculotropic MF) increased. Similar patterns were observed for CBCL; for example, the proportion of marginal-zone CBCL increased over time.

Conclusions: Changes in PCL frequencies may be explained by the emergence of new diagnostic criteria and better description of the entities in the most recent PCL classification. Moreover, we propose that an algorithm should be developed to confirm the diagnosis of PCL by central validation of the cases.

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Comment in

  • Epidemiology of cutaneous lymphoma.
    Vermeer M. Vermeer M. Br J Dermatol. 2021 Jun;184(6):993-994. doi: 10.1111/bjd.19829. Epub 2021 Mar 3. Br J Dermatol. 2021. PMID: 33656170 Free PMC article.

References

    1. Abbott RA, Aldridge C, Dojcinov S, Piguet V. Incidence of primary cutaneous T-cell lymphoma in Wales. Br J Dermatol 2013; 169:1366-7.
    1. Saunes M, Nilsen TI, Johannesen TB. Incidence of primary cutaneous T-cell lymphoma in Norway. Br J Dermatol 2009; 160:376-9.
    1. Dores GM, Anderson WF, Devesa SS. Cutaneous lymphomas reported to the National Cancer Institute’s Surveillance, Epidemiology, and End Results program: applying the new WHO-European Organisation for Research and Treatment of Cancer classification system. J Clin Oncol 2005; 23:7246-8.
    1. Beylot-Barry M, Vergier B, Masquelier B et al. The spectrum of cutaneous lymphomas in HIV infection: a study of 21 cases. Am J Surg Pathol 1999; 23:1208-16.
    1. Bouaziz JD, Bastuji-Garin S, Poszepczynska-Guigne E et al. Relative frequency and survival of patients with primary cutaneous lymphomas: data from a single-centre study of 203 patients. Br J Dermatol 2006; 154:1206-7.

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