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Review
. 2021 Jan;34(1):49-58.
doi: 10.1111/tri.13780. Epub 2020 Nov 24.

Cell therapy during machine perfusion

Emily R Thompson  1 , Chloe Connelly  1 , Simi Ali  1 , Neil S Sheerin  1 , Colin H Wilson  1
Affiliations
Free article
Review

Cell therapy during machine perfusion

Emily R Thompson et al. Transpl Int. 2021 Jan.
Free article

Abstract

There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs. This has led to the development of normothermic machine perfusion, whereby an organ is perfused with warmed, oxygenated blood and nutrients to resume normal physiological function in an isolated ex-vivo platform. With this advance in preservation comes significant opportunities to recondition, repair and regenerate organs prior to transplantation using cellular therapies. This review aims to discuss the possibilities of machine perfusion technology; highlighting the potential for organ-directed reconditioning and the future avenues for investigation in this field.

Keywords: cell therapy; machine perfusion; preservation; regenerative medicine; transplant.

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References

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