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. 2020 Nov 1;105(11):2694-2697.
doi: 10.3324/haematol.2020.253856.

Anti-C5 antibody treatment for delayed hemolytic transfusion reactions in sickle cell disease

Aline Floch  1 , Alexandre Morel  2 , Fabian Zanchetta-Balint  3 , Catherine Cordonnier-Jourdin  4 , Slimane Allali  5 , Maximilien Grall  6 , Ghislaine Ithier  7 , Benjamin Carpentier  8 , Sadaf Pakdaman  9 , Jean-Claude Merle  10 , Radjiv Goulabchand  11 , Tackwa Khalifeh  12 , Ana Berceanu  13 , Cécile Helmer  14 , Christelle Chantalat-Auger  15 , Véronique Frémeaux-Bacchi  16 , Marc Michel  17 , Mariane de Montalembert  5 , Armand Mekontso-Dessap  18 , France Pirenne  9 , Anoosha Habibi  3 , Pablo Bartolucci  3
Affiliations

Anti-C5 antibody treatment for delayed hemolytic transfusion reactions in sickle cell disease

Aline Floch et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Best mixed-effects model for total hemoglobin and lactate dehydrogenase during delayed hemolytic transfusion reaction, before and after anti-C5 antibody infusion. Hemoglobin (Hb) levels are predicted for a “theoretical” patient receiving anti-C5 antibody infusions on days 0 and 7 and no packed red blood cell (pRBC) transfusions. Before anti-C5 antibody infusion, basal total Hb concentration in this model was 51.0 g/L (the intercept of the model), with an increase of +3.8 g/L for each pRBC unit transfused, and ongoing hemolysis at a rate of -4.4 g/L for each passing day (the fixed effects of the model). However, after anti- C5 antibody infusion, Hb levels gradually increased, with a basal Hb concentration of 46.2 g/L: the effect of each transfusion was an increase of 1.58 g/L for each pRBC unit transfused and an increase in Hb levels of 0.94 g/L.
See this image and copyright information in PMC

References

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