Radiotherapy and Late Effects

Joshua D Palmer¹, Matthew D Hall², Anita Mahajan³, Arnold C Paulino⁴, Suzanne Wolden⁵, Louis S Constine⁶

Affiliations

¹ Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Nationwide Children's Hospital, Columbus, OH, USA.
² Department of Radiation Oncology, Miami Cancer Institute and Nicklaus Children's Hospital, Miami, FL, USA.
³ Department of Radiation Oncology, The Mayo Clinic, Rochester, MN, USA.
⁴ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁶ Department of Radiation Oncology, University of Rochester, Rochester, NY, USA; Department of Pediatrics, University of Rochester, Rochester, NY, USA; Department of Radiation Oncology, The Judy DiMarzo Cancer Survivorship Program, James P. Wilmot Cancer Institute, University of Rochester Medical Center, PO Box 647, Rochester, NY 14642, USA. Electronic address: Louis_Constine@urmc.rochester.edu.

PMID: 33131534
DOI: 10.1016/j.pcl.2020.08.001

Review

Radiotherapy and Late Effects

Joshua D Palmer et al. Pediatr Clin North Am. 2020 Dec.

. 2020 Dec;67(6):1051-1067.

doi: 10.1016/j.pcl.2020.08.001.

Authors

Joshua D Palmer¹, Matthew D Hall², Anita Mahajan³, Arnold C Paulino⁴, Suzanne Wolden⁵, Louis S Constine⁶

Affiliations

¹ Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Nationwide Children's Hospital, Columbus, OH, USA.
² Department of Radiation Oncology, Miami Cancer Institute and Nicklaus Children's Hospital, Miami, FL, USA.
³ Department of Radiation Oncology, The Mayo Clinic, Rochester, MN, USA.
⁴ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁶ Department of Radiation Oncology, University of Rochester, Rochester, NY, USA; Department of Pediatrics, University of Rochester, Rochester, NY, USA; Department of Radiation Oncology, The Judy DiMarzo Cancer Survivorship Program, James P. Wilmot Cancer Institute, University of Rochester Medical Center, PO Box 647, Rochester, NY 14642, USA. Electronic address: Louis_Constine@urmc.rochester.edu.

PMID: 33131534
DOI: 10.1016/j.pcl.2020.08.001

Abstract

Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects.

Keywords: Late effects; Pediatric cancer; Radiobiology; Radiotherapy.

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Conflict of interest statement

Disclosure J.D. Palmer declares grant funding from Varian Medical Systems and speaking fees from Depuy Synthes (outside the submitted work).

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Radiotherapy and Late Effects

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Radiotherapy and Late Effects

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