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Review
. 2020 Dec;67(6):1203-1217.
doi: 10.1016/j.pcl.2020.07.011. Epub 2020 Sep 23.

Renal and Hepatic Health After Childhood Cancer

Matthew J Ehrhardt  1 , Roderick Skinner  2 , Sharon M Castellino  3
Affiliations
Review

Renal and Hepatic Health After Childhood Cancer

Matthew J Ehrhardt et al. Pediatr Clin North Am. 2020 Dec.

Abstract

Childhood cancer survivors (CCSs) are at risk for renal and hepatic complications related to curative cancer treatments. Although acute renal and hepatic toxicities of cancer treatments are well described, data regarding long-term and late-occurring sequelae or their associations with acute sequelae are less robust. This article highlights the literature on the prevalence of and risk factors for late renal and hepatic toxicity in CCSs. Studies investigating these outcomes are needed to inform surveillance practices and the development of future frontline cancer treatment protocols.

Keywords: Childhood cancer; Hepatotoxicity; Late effects; Nephrotoxicity; Survivorship.

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