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. 2021 Nov 1;28(11):1195-1203.
doi: 10.5551/jat.59899. Epub 2020 Oct 30.

Associations Between Plasma Kinin B1 Receptor Levels and the Presence and Severity of Coronary Artery Disease

Yoshimi Kishimoto  1 , Masayuki Aoyama  2 , Emi Saita  3 , Yukinori Ikegami  2 , Reiko Ohmori  4 , Kazuo Kondo  5 , Yukihiko Momiyama  2
Affiliations

Associations Between Plasma Kinin B1 Receptor Levels and the Presence and Severity of Coronary Artery Disease

Yoshimi Kishimoto et al. J Atheroscler Thromb. .

Abstract

Aim: Kinin B1 receptor (KB1R) was shown to be up-regulated in human carotid atherosclerotic lesions. Serum KB1R levels were also reported to be high in patients with stroke. However, KB1R deficiency increased atherosclerotic lesions. Therefore, the role of KB1R in atherosclerosis remains unclear. Moreover, no study has reported blood KB1R levels in patients with coronary artery disease (CAD).

Methods: We measured plasma KB1R levels in 375 patients undergoing coronary angiography. The severity of CAD was represented as the numbers of ＞50% stenotic vessels and segments and the severity score.

Results: CAD was found in 197 patients, of whom 89 had 1-vessel disease (1-VD), 62 had 2-VD, and 46 had 3-VD. Plasma KB1R levels were higher in 197 patients with CAD than in 178 without CAD (median 83.3 vs. 73.7 pg/mL, p＜0.01). A stepwise increase in KB1R levels was found depending on the number of stenotic vessels: 77.1 in 1-VD, 87.8 in 2-VD, and 88.5 pg/mL in 3-VD (p＜0.025). A high KB1R level (＞90.0 pg/mL) was present in 30% of patients with CAD(-), 39% of 1-VD, 50% of 2-VD, and 48% of 3-VD (p＜0.025). KB1R levels correlated with the number of stenotic segments and the severity score (r=0.14 and r=0.17, p＜0.01). In multivariate analysis, KB1R levels were an independent factor associated with CAD. Odds ratio for CAD was 1.62 (95%CI=1.02-2.58) for high KB1R level ＞90.0 pg/mL.

Conclusion: Plasma KB1R levels in patients with CAD were high and were associated with the presence and severity of CAD independent of atherosclerotic risk factors.

Keywords: Atherosclerosis; Coronary artery disease; Kinin B1 receptor.

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Figures

Fig.1.
Fig.1.
Patients’ selection flow chart
Fig.2. Plasma KB1R levels and the presence of CAD or the number of ＞50% stenotic coronary vessels
Fig.2. Plasma KB1R levels and the presence of CAD or the number of ＞50% stenotic coronary vessels
Plasma KB1R levels were significantly higher in CAD than in CAD(-) ( p ＜0.01) (left). Moreover, KB1R levels in 4 groups of CAD(-), 1-VD, 2-VD, and 3-VD were 73.3, 77.1, 87.8, and 88.5 pg/mL, respectively, and were highest in 3-VD ( p ＜0.025 by Kruskal-Wallis test) (right). The central line represents the median, and the box represents the 25th to 75th percentiles. The whiskers represent the lowest and highest value in the 25th percentile minus 1.5 IQR and 75th percentile plus 1.5 IQR, respectively.
Fig.3. ROC curve of KB1R levels for the diagnostic ability of CAD
Fig.3. ROC curve of KB1R levels for the diagnostic ability of CAD
Regarding the diagnostic ability of KB1R levels to predict CAD, the area under ROC curve (AUC) for KB1R levels was 0.58 (95%CI=0.52–0.64).
Fig.4. Correlation between plasma KB1R level and the severity score of stenosis
Fig.4. Correlation between plasma KB1R level and the severity score of stenosis
Plasma KB1R levels significantly correlated with the severity score of coronary stenosis (rs=0.17, p ＜0.002).
See this image and copyright information in PMC

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