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Review
. 2020 Oct 22:13:10721-10727.
doi: 10.2147/OTT.S269983. eCollection 2020.

Human La Protein: An RNA-Binding Protein Involved in Ovarian Cancer Development and Multidrug Resistance

Xuan Huang  1 , Jing Tang  1
Affiliations
Review

Human La Protein: An RNA-Binding Protein Involved in Ovarian Cancer Development and Multidrug Resistance

Xuan Huang et al. Onco Targets Ther. .

Abstract

Multidrug resistance is the main cause of chemotherapy failure and death in patients with advanced ovarian cancer. Drug resistance is a problem that must be solved to improve the survival rate of patients with advanced ovarian cancer. The RNA-binding protein La and the La-related protein family are highly expressed in various malignant tumors, including ovarian cancer. This article reviews the mechanisms of La protein in tumorigenesis, development, and drug resistance. High La protein expression in tumor cells promotes tumor proliferation, invasion, and migration; disrupts cell cycle; and inhibits tumor cell apoptosis caused by chemotherapeutic drugs through various pathways, resulting in chemotherapy resistance in ovarian cancer. Further study of the role of La protein in ovarian cancer multidrug resistance may be conducive to the development of human La protein-specific inhibitors that suppress ovarian cancer drug resistance.

Keywords: La protein; Sjögren’s syndrome antigen B; chemotherapy drug resistance; multidrug resistance; ovarian cancer; ovarian cancer stem cells.

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Conflict of interest statement

The authors declare no conflicts of interest for this work.

Figures

Figure 1
Figure 1
Domain organizations among La protein and La-related protein 1 (LARP1).
Figure 2
Figure 2
Roles of La protein as a tumor promoter and multidrug resistance agent.
See this image and copyright information in PMC

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