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Case Reports
. 2020 Aug;19(4):14-18.

L-Methylfolate as a Monotherapy for Treatment-Resistant Depression: A Case Study

Angela Hardin  1 , Carrie Baldwin-Sayre  1
Affiliations
Case Reports

L-Methylfolate as a Monotherapy for Treatment-Resistant Depression: A Case Study

Angela Hardin et al. Integr Med (Encinitas). 2020 Aug.

Abstract

This case study examines a 49-year-old Asian American female patient with long-standing fatigue and depression (20 years or more), for which pharmaceutical antidepressant therapies have been ineffective. History, physical examination, laboratory tests, and Genomind Genecept Assay genetic testing were used to determine symptom severity, investigate the presence of organic causes of fatigue, and provide a potential novel monotherapy for depression. Therapeutic intervention included a slow titration of L-methylfolate to an eventual therapeutic daily dose of 15 mg.

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