Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Oct 2:11:572323.
doi: 10.3389/fimmu.2020.572323. eCollection 2020.

MicroRNAs and lncRNAs-A New Layer of Myeloid-Derived Suppressor Cells Regulation

Elham Safarzadeh  1   2 , Zahra Asadzadeh  2 , Sahar Safaei  2 , Arash Hatefi  3 , Afshin Derakhshani  2   4 , Francesco Giovannelli  4 , Oronzo Brunetti  4 , Nicola Silvestris  4   5 , Behzad Baradaran  2   6
Affiliations
Review

MicroRNAs and lncRNAs-A New Layer of Myeloid-Derived Suppressor Cells Regulation

Elham Safarzadeh et al. Front Immunol. .

Abstract

Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in several abnormal physiological conditions such as cancer. Recently, novel regulatory tumor MDSC biology modulating mechanisms, including differentiation, expansion and function, were defined. There is growing evidence that miRNAs and long non-coding RNAs (lncRNA) are involved in modulating transcriptional factors to become complex regulatory networks that regulate the MDSCs in the tumor microenvironment. It is possible that aberrant expression of miRNAs and lncRNA contributes to MDSC biological characteristics under pathophysiological conditions. This review provides an overview on miRNAs and lncRNAs epiregulation of MDSCs development and immunosuppressive functions in cancer.

Keywords: cancer; long non-coding RNAs; miRNA; molecular mechanism; myeloid-derived suppressor cells; tumor microenvironment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The role of certain miRNAs in regulation of differentiation, expansion and activation of MDSCs.
See this image and copyright information in PMC

References

    1. Serafini P, Bronte V. Myeloid-derived suppressor cells in tumor-induced T cell suppression and tolerance. In: Tumor-Induced Immune Suppression. Springer: (2008). 222:162–79. 10.3109/08820139.2012.673191 - DOI - PubMed
    1. De Sanctis F, Bronte V, Ugel S. Tumor-induced myeloid-derived suppressor cells. In: Myeloid Cells in Health and Disease: A Synthesis. (2015) 125:3365–76. 10.1172/JCI80006 - DOI - PMC - PubMed
    1. Sica A, Guarneri V, Gennari A. Myelopoiesis, metabolism and therapy: a crucial crossroads in cancer progression. Cell Stress. (2019) 3:284. 10.15698/cst2019.09.197 - DOI - PMC - PubMed
    1. Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. (2009) 9:162–74. 10.1038/nri2506 - DOI - PMC - PubMed
    1. Dai J, El Gazzar M, Li GY, Moorman JP, Yao ZQ. Myeloid-derived suppressor cells: paradoxical roles in infection and immunity. J Innate Immun. (2015) 7:116–26. 10.1159/000368233 - DOI - PMC - PubMed