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Review
. 2020 Oct 19:2020:8205983.
doi: 10.1155/2020/8205983. eCollection 2020.

The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti-Inflammatory, Antioxidant, and Antiapoptotic Activities

Jinhui Shi  1 , Ruiyue Li  1 , Siyu Yang  1 , Yeelin Phang  1 , Changwu Zheng  1 , Hongmei Zhang  1
Affiliations
Review

The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti-Inflammatory, Antioxidant, and Antiapoptotic Activities

Jinhui Shi et al. Evid Based Complement Alternat Med. .

Abstract

Ligusticum chuanxiong (LC) is a Chinese materia medica which is widely used in clinical settings to treat headaches, blood extravasation, and arthritis. Recent studies demonstrate that LC possesses versatile pharmacological functions, including antiatherosclerosis, antimigraine, antiaging, and anticancer properties. Moreover, LC also shows protective effects in the progression of different diseases that damage somatic cells. Oxidative stress and inflammation, which can induce somatic cell apoptosis, are the main factors associated with an abundance of diseases, whose progresses can be reversed by LC. In order to comprehensively review the molecular mechanisms associated with the protective effects of LC, we collected and integrated all its related studies on the anti-inflammatory, antioxidant, and antiapoptotic effects. The results show that LC could exhibit the mentioned biological activities by modulating several signaling pathways, specifically the NF-κB, Nrf2, protein kinase, and caspase-3 pathways. In future investigations, the pharmacokinetic properties of bioactive compounds in LC and the signaling pathway modulation of LC could be focused.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The molecular mechanism involves in the protective effects of LC.
Figure 2
Figure 2
The antioxidant mechanism of LC.
Figure 3
Figure 3
The antiapoptotic mechanism of LC.
See this image and copyright information in PMC

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