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. 1987 Nov;84(21):7609-13.
doi: 10.1073/pnas.84.21.7609.

Protein phosphorylation is involved in bacterial chemotaxis

J F Hess  1 , K Oosawa, P Matsumura, M I Simon
Affiliations

Protein phosphorylation is involved in bacterial chemotaxis

J F Hess et al. Proc Natl Acad Sci U S A. 1987 Nov.

Abstract

The nature of the biochemical signal that is involved in the excitation response in bacterial chemotaxis is not known. However, ATP is required for chemotaxis. We have purified all of the proteins involved in signal transduction and show that the product of the cheA gene is rapidly autophosphorylated, while some mutant CheA proteins cannot be phosphorylated. The presence of stoichiometric levels of two other purified components in the chemotaxis system, the CheY and CheZ proteins, induces dephosphorylation. We suggest that the phosphorylation of CheA by ATP plays a central role in signal transduction in chemotaxis.

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References

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