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. 2020 May 25;4(5):pkaa044.
doi: 10.1093/jncics/pkaa044. eCollection 2020 Oct.

The Relative Impact of Urinary and Sexual Function vs Bother on Health Utility for Men With Prostate Cancer

Chang Wook Jeong  1   2 , Annika Herlemann  1   3 , Janet E Cowan  1 , Jeanette M Broering  1 , Renske M T Ten Ham  4   5 , Leslie S Wilson  4 , Peter R Carroll  1 , Matthew R Cooperberg  1   6
Affiliations

The Relative Impact of Urinary and Sexual Function vs Bother on Health Utility for Men With Prostate Cancer

Chang Wook Jeong et al. JNCI Cancer Spectr. .

Abstract

Function and bother are related but distinct aspects of health-related quality of life. The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of health-related quality of life in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1617 men. Linear regression on the patients' function and bother summary scores (0-100) from the University of California, Los Angeles Prostate Cancer Index was performed to predict bias-corrected health utilities. Urinary and sexual bother were associated with each health utility, and their coefficients were 3.7 and 20.8 times greater, respectively, than those of the corresponding function. To our knowledge, our study provides the first quantitative and direct comparison of the impacts of function vs bother on health utility.

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  • Letter to the editor: Reply to Chen et al.
    Heemsbergen WD, de Vries KC, Incrocci L. Heemsbergen WD, et al. Clin Transl Radiat Oncol. 2025 May 9;53:100979. doi: 10.1016/j.ctro.2025.100979. eCollection 2025 Jul. Clin Transl Radiat Oncol. 2025. PMID: 40476149 Free PMC article.

References

    1. Barocas DA, Alvarez J, Resnick MJ, et al.Association between radiation therapy, surgery, or observation for localized prostate cancer and patient-reported outcomes after 3 years. JAMA. 2017;317(11):1126–1140. - PMC - PubMed
    1. Reeve BB, Potosky AL, Willis GB. Should function and bother be measured and reported separately for prostate cancer quality-of-life domains? Urology. 2006;68(3):599–603. - PubMed
    1. Cooperberg MR, Koppie TM, Lubeck DP, et al.How potent is potent? Evaluation of sexual function and bother in men who report potency after treatment for prostate cancer: data from CaPSURE. Urology. 2003;61(1):190–196. - PubMed
    1. Donovan KA, Gonzalez BD, Nelson AM, et al.Effect of androgen deprivation therapy on sexual function and bother in men with prostate cancer: a controlled comparison. Psychooncology. 2018;27(1):316–324. - PMC - PubMed
    1. Le JD, Cooperberg MR, Sadetsky N, et al.Changes in specific domains of sexual function and sexual bother after radical prostatectomy. BJU Int. 2010;106(7):1022–1029. - PubMed