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. 2021 Feb;81(1):60-70.
doi: 10.1002/jdn.10075. Epub 2020 Nov 20.

Acrobatic exercise recovers object recognition memory impairment in hypoxic-ischemic rats

Wellington de Almeida  1   2 , Heloísa Deola Confortim  1   3 , Bruna Ferrary Deniz  1   2 , Patrícia Maidana Miguel  1   2 , Milene Cardoso Vieira  2 , Loise Bronauth  2 , Adriana Souza Dos Santos  1   2 , Karine Bertoldi  4 , Ionara Rodrigues Siqueira  4   5 , Lenir Orlandi Pereira  1   2
Affiliations

Acrobatic exercise recovers object recognition memory impairment in hypoxic-ischemic rats

Wellington de Almeida et al. Int J Dev Neurosci. 2021 Feb.

Abstract

Neonatal hypoxia-ischemia (HI) can lead to cognitive impairments and motor dysfunction. Acrobatic exercises (AE) were proposing as therapeutic option to manage HI motor deficits, however, the cognitive effects after this treatment are still poorly understood. Therefore, we evaluated the effects of AE protocol on memory impairments and brain plasticity markers after Rice-Vannucci HI rodent model. Wistar rats on the 7th postnatal day (PND) were submitted to HI model and after weaning (PND22) were trained for 5 weeks with AE protocol, then subsequently submitted to cognitive tests. Our results showed recovery in novel object recognition (NOR) memory, but not, spatial Morris Water Maze (WM) memory after AE treatment in HI rats. BDNF and synaptophysin neuroplasticity markers indicate plastic alterations in the hippocampus and striatum, with maintenance of synaptophysin despite the reduction of total volume tissue, besides, hippocampal HI-induced ipsilateral BDNF increased, and striatum contralateral BDNF decreased were noted. Nevertheless, the exercise promoted functional recovery and seems to be a promising strategy for HI treatment, however, future studies identifying neuroplastic pathway for this improvement are needed.

Keywords: coordination training; developmental brain disorder; motor skill learning; neural development; perinatal asphyxia.

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References

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