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. 2021 Jun 1;41(6):1193-1201.
doi: 10.1097/IAE.0000000000003001.

SERUM LEVELS OF ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES ARE DECREASED IN PATIENTS WITH RETINAL VEIN OCCLUSION

Laura Posch-Pertl  1 , Martin Weger  1 , Silke Pinter-Hausberger  1 , Wolfgang List  1 , Florian Posch  2 , Andreas Wedrich  1 , Katharina Michelitsch  1 , Maria O Kozma  3 , Nora Woltsche  1 , Christoph J Binder  3
Affiliations

SERUM LEVELS OF ANTIBODIES AGAINST OXIDATION-SPECIFIC EPITOPES ARE DECREASED IN PATIENTS WITH RETINAL VEIN OCCLUSION

Laura Posch-Pertl et al. Retina. .

Abstract

Purpose: Oxidative stress and inflammation have been implicated in the development of retinal vein occlusion (RVO). Oxidation-specific epitopes (OSEs) represent products of oxidative stress that can trigger vascular inflammation and thrombosis. Natural occurring antibodies have been shown to bind oxidation-specific epitopes thereby inhibiting their inflammatory potential and promoting their removal.

Methods: This prospective cross-sectional study included 270 patients with RVO and 81 in-hospital control patients. We measured three types of serum levels of oxidation-specific epitope-specific immunoglobulin M and immunoglobulin G antibodies (anti-copper-oxidized LDL [CuOx-LDL], antiphosphocholine [PC], anti-malondialdehyde-modified LDL [MDA-LDL]). History of arterial hypertension, hyperlipidemia, myocardial infarction, diabetes mellitus, stroke, smoking status, and several laboratory parameters were determined to control for potential confounders.

Results: Compared with controls, patients with RVO had significantly lower levels of immunoglobulin M and immunoglobulin G antibodies against CuOx-LDL and PC, and significantly lower levels of immunoglobulin G but not immunoglobulin M antibodies against MDA-LDL. The association between RVO patients and lower levels of these antibodies prevailed upon multivariable adjustment.

Conclusion: These prospective data show that antibodies against oxidation-specific epitope are lower in patients with RVO compared with control patients and support the concept that oxidative stress and inflammation play key roles in the development and subsequent complications in RVO.

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References

    1. Jaulim A, Ahmed B, Khanam T, et al. Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina 2013;33:901–910.
    1. Ponto KA, Elbaz H, Peto T, et al. Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study. J Thromb Haemost 2015;13:1254–1263.
    1. Zhou JQ, Xu L, Wang S, et al. The 10-year incidence and risk factors of retinal vein occlusion: the Beijing eye study. Ophthalmology 2013;120:803–808.
    1. Chen YY, Sheu SJ, Hu HY, et al. Association between retinal vein occlusion and an increased risk of acute myocardial infarction: a nationwide population-based follow-up study. PLoS One 2017;12:e0184016.
    1. Li M, Hu X, Huang J, et al. Impact of retinal vein occlusion on stroke incidence: a meta-analysis. J Am Heart Assoc 2016;5:e004703.

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