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Meta-Analysis
. 2020 Nov 2;20(1):364.
doi: 10.1186/s12876-020-01491-w.

Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis

Yuan-Chen Wang  1 , Jun Pan  1 , Ya-Wei Liu  2 , Feng-Yuan Sun  1 , Yang-Yang Qian  1 , Xi Jiang  1 , Wen-Bin Zou  1 , Ji Xia  1 , Bin Jiang  1 , Nan Ru  1 , Jia-Hui Zhu  1 , En-Qiang Linghu  3 , Zhao-Shen Li  1 , Zhuan Liao  4
Affiliations
Meta-Analysis

Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis

Yuan-Chen Wang et al. BMC Gastroenterol. .

Abstract

Background: A full spectrum of video capsule endoscopy (VCE) adverse events over the past two decades has not been evaluated. We aimed to determine pooled rates, predictors and temporal-trend of VCE adverse events over the past two decades.

Methods: Systematic search of PubMed and EMBASE for English-language publications reporting VCE adverse events (January 1, 2000 to March 31, 2019). Data were extracted independently by two investigators. Pooled VCE adverse event rates were calculated using the random or fixed model as appropriate. Predictors and temporal-trend of each adverse event were performed by meta-regression analyses.

Results: In total, 402 studies were identified, including 108,079 VCE procedures. Rate of retention, swallow disorder, aspiration, technical failure, and procedural adverse events were 0.73% (95% confidence interval [CI] 0.59-0.89%), 0.75% (95% CI 0.43-1.13%), 0.00% (95% CI 0.00-0.00%), 0.94% (95% CI 0.65-1.28%), 0.67% (95% CI 0.32-1.10%), respectively; incomplete examination rate of esophagus, stomach, small bowel, and colon were 9.05%, 7.69%, 12.08%, 19.19%, respectively. Patency capsule reduced retention rate by 5.04%, whereas known inflammatory bowel disease increased retention rate by 4.29%. Elder was the risk and protective factor for small bowel incomplete examination (0.30%) and swallow disorder (- 0.72%), respectively. Rates of retention and small bowel incomplete examination significantly declined over time (P = .0006 and P < .0001)..

Conclusions: VCE adverse event rates were generally low, and retention and small bowel incomplete examination rates declined over the past two decades. Patients with known inflammatory bowel disease or elder should be alerted to high risk of retention or small bowel incomplete examination (PROSPERO: CRD42019139595).

Keywords: Adverse events; Predictors; Systematic review and meta-analysis; Temporal-trend; Video capsule endoscopy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The flowchart of the study selection process
Fig. 2
Fig. 2
Time-trend analysis of VCE adverse events rates. a Retention rate, b small bowel incomplete examination rate, c colon incomplete examination rate, d swallow disorder rate, e technical failure rate, f procedural adverse events rate
See this image and copyright information in PMC

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