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Comment
. 2021 Jan;147(1):112-113.
doi: 10.1016/j.jaci.2020.09.026. Epub 2020 Oct 26.

Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19

Eva Luecke  1 , Andreas Jeron  2 , Andrea Kroeger  3 , Dunja Bruder  2 , Sabine Stegemann-Koniszewski  4 , Doerthe Jechorek  5 , Katrin Borucki  6 , Dirk Reinhold  7 , Annegret Reinhold  7 , Sebastian Foellner  4 , Thorsten Walles  8 , Thomas Hachenberg  9 , Jens Schreiber  4
Affiliations
Comment

Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19

Eva Luecke et al. J Allergy Clin Immunol. 2021 Jan.
No abstract available

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Figures

Fig 1
Fig 1
Histology of lung parenchyma resected on day 40 after intubation (8 days after initiation of prednisolone therapy) histology showed diffuse alveolar damage of proliferative organizing phase: polypoid plugs of loose organizing connective tissue protruding into the alveolar ducts (arrows) (A, hematoxylin-eosin, B, Masson-Trichrome), prominent type 2 pneumocyte hyperplasia with cytologic atypia (C, pancytokeratine, red), and alveolar macrophage accumulation (C, CD68, brown). Focally, peribronchial interstitial chronic inflammation with dominating CD3+ CD8+ T cells (D, CD3, E, CD8) and single CD20+ B cells (F) was observed. Patchy subpleural accentuated acute hemorrhage (asterisks) and vasculitis with endothelial swelling, fibrinoid necrosis, and transmural eosinophilic infiltrate (arrows) (G-I) were observed.
See this image and copyright information in PMC

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