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Comment
. 2020 Nov;10(11):1632-1634.
doi: 10.1158/2159-8290.CD-20-1251.

Free Asparagine or Die: Cancer Cells Require Proteasomal Protein Breakdown to Survive Asparagine Depletion

Kristian Davidsen  1   2 , Lucas B Sullivan  3   4
Affiliations
Comment

Free Asparagine or Die: Cancer Cells Require Proteasomal Protein Breakdown to Survive Asparagine Depletion

Kristian Davidsen et al. Cancer Discov. 2020 Nov.

Abstract

The chemotherapeutic enzyme asparaginase depletes systemic asparagine to kill cancers; however, its efficacy thus far is limited to a subset of leukemias. Hinze and colleagues identify that inhibiting proteasomal release of asparagine can sensitize colorectal cancers to asparagine depletion, providing a potential avenue to repurpose asparaginase for treatment of solid tumors.See related article by Hinze et al., p. 1690.

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References

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