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Comment
. 2021 Jan;18(1):7-8.
doi: 10.1038/s41571-020-00448-y.

Pragmatic trials with prespecified subgroups: what oncologists can learn from COVID-19

Rahul Banerjee  1 , Vinay Prasad  2   3   4
Affiliations
Comment

Pragmatic trials with prespecified subgroups: what oncologists can learn from COVID-19

Rahul Banerjee et al. Nat Rev Clin Oncol. 2021 Jan.

Abstract

Randomized controlled trials designed to test cancer therapies often fail to clarify effectiveness in real-world settings. Herein, we explore lessons for trial development in oncology that can be learnt from the large-cohort, pragmatic RECOVERY trial involving patients hospitalized with COVID-19.

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Conflict of interest statement

V.P. has acted as a consultant of UnitedHealthcare, has received research funding from Arnold Ventures, has received royalties from Johns Hopkins Press and Medscape, has received speaker’s fees from Evicore and for Grand Rounds/lectures from various universities, medical centres, non-profit organizations, and professional societies and has received financial support for the Plenary Session series of podcasts via Patreon. R.B. declares no competing interests.

Comment on

  • Dexamethasone in Hospitalized Patients with Covid-19.
    RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. N Engl J Med. 2021. PMID: 32678530 Free PMC article. Clinical Trial.

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