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Comment
. 2020 Dec;30(12):1057-1058.
doi: 10.1038/s41422-020-00427-z.

Resident macrophages keep mitochondria running in the heart

Ronald J Vagnozzi  1   2 , Jeffery D Molkentin  3   4
Affiliations
Comment

Resident macrophages keep mitochondria running in the heart

Ronald J Vagnozzi et al. Cell Res. 2020 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1. Cardiac-resident macrophages maintain cellular and functional homeostasis in the heart.
a Cardiac tissue macrophages (cMacs: CD45+ CD11b+ F4/80+ and marked by CX3CR1-GFP) reside in the interstitial compartment of the heart at baseline, with multiple cMacs surrounding each cardiac myocyte. cMacs actively phagocytose mitochondrial debris released from cardiac myocytes under physiological conditions, via the receptor tyrosine kinase Mertk. b Genetic ablation of cMacs using CD169-driven DTR, or knockout of Mertk, triggers accumulation of mitochondrial debris, impaired autophagy, and NLRP3 inflammasome activation, resulting in compromised heart function and metabolic derangement. Illustration was created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.
    Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A. Nicolás-Ávila JA, et al. Cell. 2020 Oct 1;183(1):94-109.e23. doi: 10.1016/j.cell.2020.08.031. Epub 2020 Sep 15. Cell. 2020. PMID: 32937105

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References

    1. Murphy E, et al. Circ. Res. 2016;118:1960–1991. doi: 10.1161/RES.0000000000000104. - DOI - PMC - PubMed
    1. Henning RH, Brundel B. Nat. Rev. Cardiol. 2017;14:637–653. doi: 10.1038/nrcardio.2017.89. - DOI - PubMed
    1. Forte E, Furtado MB, Rosenthal N. Nat. Rev. Cardiol. 2018;15:601–616. doi: 10.1038/s41569-018-0077-x. - DOI - PubMed
    1. Pinto AR, et al. Circ. Res. 2016;118:400–409. doi: 10.1161/CIRCRESAHA.115.307778. - DOI - PMC - PubMed
    1. Epelman S, et al. Immunity. 2014;40:91–104. doi: 10.1016/j.immuni.2013.11.019. - DOI - PMC - PubMed