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. 2021 Jun;44(3):846-858.
doi: 10.1007/s10753-020-01379-7. Epub 2020 Nov 2.

The Effect of Porphyromonas gingivalis Lipopolysaccharide on the Pyroptosis of Gingival Fibroblasts

Yu-Yang Li  1   2 , Qing Cai  1 , Bao-Sheng Li  1 , Shu-Wei Qiao  1   2 , Jia-Yang Jiang  1   2 , Dan Wang  1   2 , Xue-Chun Du  1   2 , Wei-Yan Meng  3
Affiliations

The Effect of Porphyromonas gingivalis Lipopolysaccharide on the Pyroptosis of Gingival Fibroblasts

Yu-Yang Li et al. Inflammation. 2021 Jun.

Abstract

Periodontitis is a chronic inflammatory disease induced by Porphyromonas gingivalis (P. gingivalis) and other pathogens. P. gingivalis release various virulence factors including lipopolysaccharide (LPS). However, whether P. gingivalis-LPS inducing pyroptosis in human gingival fibroblasts (HGFs) remains unknown. In present study, P. gingivalis-LPS decreased the membrane integrity of HGFs, and pyroptosis-associated cytokines were upregulated at the mRNA level. In addition, pyroptosis proteins were highly expressed in gingival tissues of periodontitis. P. gingivalis-LPS induced gingivitis in the rat model, and the expression level of pyroptosis-associated proteins increased. Together, P. gingivalis-LPS can activate the pyroptosis reaction, which may be a pro-pyroptosis status in a relative low concentration.

Keywords: Porphyromonas gingivalis; fibroblast; lipopolysaccharide; programmed cell death; pyroptosis.

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