Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec;198(6):939-945.
doi: 10.1007/s00408-020-00401-x. Epub 2020 Nov 3.

Obstructive Sleep Apnea Severity, Body Mass Index, and Circulating Levels of Cellular Adhesion Molecules

Bernardo U Peres  1 , A J Hirsch Allen  2 , Tetyana Kendzerska  3 , Aditi Shah  2   4 , Nurit Fox  2 , Ismail Laher  2 , Fernanda Almeida  1 , Rachel Jen  2   4 , Andrew J Sandford  5 , Stephan F van Eeden  5 , Najib T Ayas  6   7   8
Affiliations

Obstructive Sleep Apnea Severity, Body Mass Index, and Circulating Levels of Cellular Adhesion Molecules

Bernardo U Peres et al. Lung. 2020 Dec.

Abstract

Purpose: To investigate the relationship between obstructive sleep apnea (OSA) severity, body mass index (BMI), and circulating levels of inflammatory adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin).

Methods: A cross-sectional clinical cohort study on all consecutive adults referred to the University of British Columbia (UBC) Sleep Laboratory for a polysomnogram (PSG) for suspected OSA provided a morning blood sample. Samples were analyzed with multiplex immune assay (MilliporeSigma, CA) to assess the levels of adhesion molecules.

Results: 488 patients were studied; the majority were male (68%) with a mean age of 50 yrs, mean AHI of 23 events/hour, and mean BMI of 32 kg/m2. In multivariable linear regression models, all three adhesion molecules were significantly associated with BMI (E-selectin p < 0.0001; ICAM-1 p = 0.0007; VCAM-1 p = 0.0003). However, only E-selectin was independently associated with AHI (p = 0.02); there was no significant interaction between AHI and BMI for E-selectin (p = 0.33).

Conclusions: Although all three adhesion molecules were associated with BMI, only E-selectin was independently associated with OSA severity. Future studies are needed to determine the clinical significance of the relationship between E-selectin and OSA.

Keywords: Adult; Biomarkers; Blood; Obesity; Obstructive sleep apnea(OSA).

PubMed Disclaimer

References

    1. Benjafield AV, Ayas NT, Eastwood PR et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7:687–698 - DOI
    1. Peppard PE (2000) Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 284:3015 - DOI
    1. Marin JM, Agusti A, Villar I et al (2012) Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA 307:2169–2176 - DOI
    1. Ridker PM (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836–843 - DOI
    1. Pak VM, Keenan BT, Jackson N et al (2015) Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. Int J Obes 39:472–479 - DOI

Publication types

LinkOut - more resources