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Review
. 2021 Apr;99(4):351-360.
doi: 10.1111/imcb.12422. Epub 2020 Nov 24.

Autophagy in T-cell differentiation, survival and memory

Liqing Wang  1   2 , Jugal Kishore Das  1 , Anil Kumar  1 , Hao-Yun Peng  1   2 , Yijie Ren  1 , Xiaofang Xiong  1 , Jin-Ming Yang  3 , Jianxun Song  1
Affiliations
Review

Autophagy in T-cell differentiation, survival and memory

Liqing Wang et al. Immunol Cell Biol. 2021 Apr.

Abstract

Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

Keywords: T cells.; autophagy; differentiation; immunotherapy; memory; survival.

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