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Review
. 2020 Oct 30;25(21):5051.
doi: 10.3390/molecules25215051.

Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care

Ying-Chen Cheng  1 , Tzong Shiun Li  2 , Hong Lin Su  3 , Po Chun Lee  4 , Hui-Min David Wang  1   5   6
Affiliations
Review

Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care

Ying-Chen Cheng et al. Molecules. .

Abstract

Natural products are favored because of their non-toxicity, low irritants, and market reacceptance. We collected examples, according to ancient wisdom, of natural products to be applied in transdermal delivery. A transdermal delivery system, including different types of agents, such as ointments, patches, and gels, has long been used for skin concerns. In recent years, many novel transdermal applications, such as nanoemulsions, liposomes, lipid nanoparticles, and microneedles, have been reported. Nanosized drug delivery systems are widely applied in natural product deliveries. Nanosized materials notably enhance bioavailability and solubility, and are reported to improve the transdermal permeation of many substances compared with conventional topical formulations. Natural products have been made into nanosized biomaterials in order to enhance the penetration effect. Before introducing the novel transdermal applications of natural products, we present traditional methods within this article. The descriptions of novel transdermal applications are classified into three parts: liposomes, emulsions, and lipid nanoparticles. Each section describes cases that are related to promising natural product transdermal use. Finally, we summarize the outcomes of various studies on novel transdermal agents applied to skin treatments.

Keywords: emulsion; lipid nanoparticle; liposome; natural products; skin; transdermal delivery.

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Conflict of interest statement

The authors have no competing financial interests to declare.

Figures

Figure 1
Figure 1
The applications, challenges, and technologies of natural product delivery on human skin.
Figure 2
Figure 2
Scientists developed novel vector to expand the application of natural products.
Figure 3
Figure 3
Natural products in various types of therapeutic bio-functions.
See this image and copyright information in PMC

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