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Meta-Analysis
. 2020 Oct 30;17(21):8015.
doi: 10.3390/ijerph17218015.

Effect of per Capita Income on the Relationship between Periodontal Disease during Pregnancy and the Risk of Preterm Birth and Low Birth Weight Newborn. Systematic Review and Meta-Analysis

Carmen Alba Moliner-Sánchez  1 , José Enrique Iranzo-Cortés  1 , José Manuel Almerich-Silla  1 , Carlos Bellot-Arcís  1 , José Carmelo Ortolá-Siscar  1 , José María Montiel-Company  1 , Teresa Almerich-Torres  1
Affiliations
Meta-Analysis

Effect of per Capita Income on the Relationship between Periodontal Disease during Pregnancy and the Risk of Preterm Birth and Low Birth Weight Newborn. Systematic Review and Meta-Analysis

Carmen Alba Moliner-Sánchez et al. Int J Environ Res Public Health. .

Abstract

This work analyzed the available evidence in the scientific literature about the risk of preterm birth and/or giving birth to low birth weight newborns in pregnant women with periodontal disease. A systematic search was carried out in three databases for observational cohort studies that related periodontal disease in pregnant women with the risk of preterm delivery and/or low birth weight, and that gave their results in relative risk (RR) values. Eleven articles were found, meeting the inclusion criteria. Statistically significant values were obtained regarding the risk of preterm birth in pregnant women with periodontitis (RR = 1.67 (1.17-2.38), 95% confidence interval (CI)), and low birth weight (RR = 2.53 (1.61-3.98) 95% CI). When a meta-regression was carried out to relate these results to the income level of each country, statistically significant results were also obtained; on the one hand, for preterm birth, a RR = 1.8 (1.43-2.27) 95% CI was obtained and, on the other hand, for low birth weight, RR = 2.9 (1.98-4.26) 95% CI. A statistically significant association of periodontitis, and the two childbirth complications studied was found, when studying the association between these results and the country's per capita income level. However, more studies and clinical trials are needed in this regard to confirm the conclusions obtained.

Keywords: income level; low birth weight; meta-analysis; periodontal disease; premature birth; risk factor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram.
Figure 2
Figure 2
Forest plot of preterm labor.
Figure 3
Figure 3
Forest plot low birth weight.
Figure 4
Figure 4
Funnel plot for preterm labor (a) and low birth weight (b).
Figure 5
Figure 5
Scatter plot for preterm labor and socio-economic level of the country.
Figure 6
Figure 6
Scatter plot for low birth weight and socio-economic level.
See this image and copyright information in PMC

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