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Review
. 2020 Oct 30;21(21):8141.
doi: 10.3390/ijms21218141.

Cardiovascular Disease and SARS-CoV-2: the Role of Host Immune Response Versus Direct Viral Injury

Federico Biscetti  1   2   3 , Maria Margherita Rando  2 , Elisabetta Nardella  2 , Andrea Leonardo Cecchini  2 , Piergiorgio Bruno  1   4 , Raffaele Landolfi  1   2   4   5 , Andrea Flex  1   2   3   4   5
Affiliations
Review

Cardiovascular Disease and SARS-CoV-2: the Role of Host Immune Response Versus Direct Viral Injury

Federico Biscetti et al. Int J Mol Sci. .

Abstract

The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.

Keywords: SARS-CoV-2; cardiovascular diseases.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cardiovascular involvement of SARS-CoV-2 during the various stages of the disease.
See this image and copyright information in PMC

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