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. 2020 Dec;34(12):1461-1465.
doi: 10.1177/0269881120959608. Epub 2020 Nov 4.

Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression

Liliana P Capitão  1   2 , Robert Chapman  1   2 , Nicola Filippini  1   3 , Lucy Wright  1   2 , Susannah E Murphy  1   2 , Anthony James  1   2 , Phil J Cowen  1   2 , Catherine J Harmer  1   2
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Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression

Liliana P Capitão et al. J Psychopharmacol. 2020 Dec.

Abstract

Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research.

Keywords: Fluoxetine; adolescent depression; resting-state functional connectivity.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The authors have links with industry agencies and/or consulting companies not involved in this study. Specifically, LC served as a consultant to P1vital, a contract research organisation that runs industry-sponsored experimental medicine studies in academic departments. SM has also served as a consultant to P1vital and has participated in paid speaking engagements for Eli Lilly and Co. CH receives consultancy fees from and has shares in P1vital. She has also received consultancy fees from Lundbeck, Johnson and Johnson (J&J) and Servier, and has received grant income from J&J and UCB. The other authors declare that they have no conflict of interests.

Figures

Figure 1.
Figure 1.
Axial, coronal and sagittal slices of the main RSNs detected, overlaid onto the standard Montreal Neurological Institute brain.
Figure 2.
Figure 2.
(a) Region of reduced connectivity with the motor network, the precentral/postcentral gyrus is shown. (b) Significantly reduced functional connectivity in the MDD group on fluoxetine compared with placebo between the motor network and a cluster containing the precentral and postcentral gyrus. p < 0.05.
See this image and copyright information in PMC

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