Meta-Analysis
doi: 10.1158/1055-9965.EPI-20-0739.
Epub 2020 Nov 3.
Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers
Dylan M Glubb
1
, Deborah J Thompson
2
, Katja K H Aben
3
4
, Ahmad Alsulimani
5
, Frederic Amant
6
, Daniela Annibali
6
, John Attia
7
8
, Aurelio Barricarte
9
10
11
, Matthias W Beckmann
12
, Andrew Berchuck
13
, Marina Bermisheva
14
, Marcus Q Bernardini
15
, Katharina Bischof
16
17
, Line Bjorge
16
17
, Clara Bodelon
18
, Alison H Brand
19
20
, James D Brenton
21
, Louise A Brinton
18
, Fiona Bruinsma
22
, Daniel D Buchanan
23
24
25
26
, Stefanie Burghaus
12
, Ralf Butzow
27
, Hui Cai
28
, Michael E Carney
29
, Stephen J Chanock
30
, Chu Chen
31
, Xiao Qing Chen
1
, Zhihua Chen
32
, Linda S Cook
33
34
, Julie M Cunningham
35
, Immaculata De Vivo
36
37
, Anna deFazio
19
38
, Jennifer A Doherty
39
, Thilo Dörk
40
, Andreas du Bois
41
42
, Alison M Dunning
43
, Matthias Dürst
44
, Todd Edwards
45
, Robert P Edwards
46
47
, Arif B Ekici
48
, Ailith Ewing
2
, Peter A Fasching
12
49
, Sarah Ferguson
15
, James M Flanagan
50
, Florentia Fostira
51
, George Fountzilas
52
, Christine M Friedenreich
34
, Bo Gao
38
53
, Mia M Gaudet
54
, Jan Gawełko
55
, Aleksandra Gentry-Maharaj
56
, Graham G Giles
22
24
57
, Rosalind Glasspool
58
, Marc T Goodman
59
, Jacek Gronwald
60
, Holly R Harris
61
62
, Philipp Harter
41
, Alexander Hein
12
, Florian Heitz
41
, Michelle A T Hildebrandt
63
, Peter Hillemanns
40
, Estrid Høgdall
64
65
, Claus K Høgdall
66
, Elizabeth G Holliday
7
8
, David G Huntsman
67
68
69
70
, Tomasz Huzarski
71
72
, Anna Jakubowska
60
73
, Allan Jensen
64
, Michael E Jones
74
, Beth Y Karlan
75
, Anthony Karnezis
76
, Joseph L Kelley
47
, Elza Khusnutdinova
14
77
, Jeffrey L Killeen
78
, Susanne K Kjaer
64
79
, Rüdiger Klapdor
80
, Martin Köbel
81
, Bozena Konopka
82
, Irene Konstantopoulou
51
, Reidun K Kopperud
16
17
, Madhuri Koti
83
, Peter Kraft
37
84
, Jolanta Kupryjanczyk
82
, Diether Lambrechts
85
86
, Melissa C Larson
87
, Loic Le Marchand
88
, Shashikant Lele
89
, Jenny Lester
75
, Andrew J Li
90
, Dong Liang
91
, Clemens Liebrich
92
, Loren Lipworth
93
, Jolanta Lissowska
94
, Lingeng Lu
95
, Karen H Lu
96
, Alessandra Macciotta
97
, Amalia Mattiello
98
, Taymaa May
15
, Jessica N McAlpine
99
, Valerie McGuire
100
, Iain A McNeish
101
102
, Usha Menon
56
, Francesmary Modugno
47
103
, Kirsten B Moysich
5
, Heli Nevanlinna
104
, Kunle Odunsi
89
, Håkan Olsson
105
, Sandra Orsulic
90
, Ana Osorio
106
107
, Domenico Palli
108
, Tjoung-Won Park-Simon
40
, Celeste L Pearce
109
110
, Tanja Pejovic
111
112
, Jennifer B Permuth
113
, Agnieszka Podgorska
82
, Susan J Ramus
114
115
, Timothy R Rebbeck
116
117
, Marjorie J Riggan
13
, Harvey A Risch
95
, Joseph H Rothstein
118
119
, Ingo B Runnebaum
44
, Rodney J Scott
7
120
121
, Thomas A Sellers
113
, Janine Senz
67
68
, Veronica Wendy Setiawan
122
, Nadeem Siddiqui
123
, Weiva Sieh
118
119
, Beata Spiewankiewicz
124
, Rebecca Sutphen
125
, Anthony J Swerdlow
74
126
, Lukasz Michael Szafron
127
, Soo Hwang Teo
128
129
, Pamela J Thompson
59
, Liv Cecilie Vestrheim Thomsen
16
17
, Linda Titus
130
, Alicia Tone
15
, Rosario Tumino
131
, Constance Turman
37
, Adriaan Vanderstichele
132
, Digna Velez Edwards
133
, Ignace Vergote
132
, Robert A Vierkant
87
, Zhaoming Wang
18
, Shan Wang-Gohrke
134
, Penelope M Webb
135
; OPAL Study Group; AOCS Group; Emily White
62
136
, Alice S Whittemore
100
137
, Stacey J Winham
87
, Xifeng Wu
63
, Anna H Wu
122
, Drakoulis Yannoukakos
51
, Amanda B Spurdle
1
, Tracy A O'Mara
138
Affiliations
Affiliations
- 1 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 2 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 3 Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 4 Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.
- 5 Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
- 6 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
- 7 Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
- 8 Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
- 9 CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
- 10 Navarra Public Health Institute, Pamplona, Spain.
- 11 Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
- 12 Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
- 13 Department of Gynecologic Oncology, Duke University Hospital, Durham, North Carolina.
- 14 Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
- 15 Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.
- 16 Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
- 17 Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 18 Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
- 19 Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
- 20 University of Sydney, Sydney, New South Wales, Australia.
- 21 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
- 22 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 23 Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
- 24 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 25 Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
- 26 University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
- 27 Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 28 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
- 29 John A. Burns School of Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, Hawaii.
- 30 Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, Maryland.
- 31 Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 32 Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida.
- 33 University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico.
- 34 Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.
- 35 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
- 36 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
- 37 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
- 38 Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
- 39 Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
- 40 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 41 Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany.
- 42 Praxis für Humangenetik, Wiesbaden, Germany.
- 43 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
- 44 Department of Gynaecology, Jena University Hospital- Friedrich Schiller University, Jena, Germany.
- 45 Division of Epidemiology, Center for Human Genetics Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
- 46 Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
- 47 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
- 48 Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
- 49 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California.
- 50 Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.
- 51 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos," Athens, Greece.
- 52 Second Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
- 53 The Crown Princess Mary Cancer Centre Westmead, Sydney-West Cancer Network, Westmead Hospital, Sydney, New South Wales, Australia.
- 54 Department of Population Science, American Cancer Society, Atlanta, Georgia.
- 55 Institute of Nursing and Health Sciences, Medical Faculty, University of Rzeszów, Rzeszów, Poland.
- 56 MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
- 57 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
- 58 Department of Medical Oncology, Beatson West of Scotland Cancer Centre and University of Glasgow, Glasgow, UK.
- 59 Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.
- 60 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 61 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 62 Department of Epidemiology, University of Washington, Seattle, Washington.
- 63 Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
- 64 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
- 65 Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
- 66 The Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 67 British Columbia's Ovarian Cancer Research (OVCARE) Program, BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.
- 68 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
- 69 Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
- 70 Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
- 71 Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
- 72 Department of Genetics and Pathology, University of Zielona Góra, Zielona Góra, Poland.
- 73 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
- 74 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 75 David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California.
- 76 Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California.
- 77 Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.
- 78 Department of Pathology, Kapiolani Medical Center for Women and Children, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
- 79 Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 80 Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
- 81 Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada.
- 82 Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
- 83 Departments of Biomedical and Molecular Sciences and Obstetrics and Gynaecology, Cancer Biology and Genetics Division, Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
- 84 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
- 85 VIB Center for Cancer Biology, Leuven, Belgium.
- 86 Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
- 87 Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
- 88 Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
- 89 Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York.
- 90 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
- 91 College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas.
- 92 Clinics of Gynaecology, Cancer Center Wolfsburg, Wolfsburg, Germany.
- 93 Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
- 94 Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland.
- 95 Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
- 96 Department of Gynecologic Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas.
- 97 Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany.
- 98 Dipertimento Di Medicina Clinca e Chirurgia, Federico II University, Naples, Italy.
- 99 British Columbia's Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver General Hospital and BC Cancer, Vancouver, BC, Canada.
- 100 Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.
- 101 Division of Cancer and Ovarian Cancer Action Research Centre, Department Surgery and Cancer, Imperial College London, London, UK.
- 102 Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
- 103 Womens Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
- 104 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 105 Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
- 106 Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
- 107 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
- 108 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
- 109 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
- 110 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
- 111 Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.
- 112 Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
- 113 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
- 114 School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, New South Wales, Australia.
- 115 Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia.
- 116 Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
- 117 Dana-Farber Cancer Institute, Boston, Massachusetts.
- 118 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
- 119 Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
- 120 Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.
- 121 Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia.
- 122 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
- 123 Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
- 124 Tytus Chałbiński Specialist Hospital in Radom, Warsaw, Poland.
- 125 Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida.
- 126 Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
- 127 Department of Immunology, the Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland.
- 128 Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
- 129 Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
- 130 Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
- 131 Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany.
- 132 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
- 133 Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Women's Health Research, Vanderbilt University Medical Center, Nashville, Tennessee.
- 134 Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
- 135 Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 136 Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 137 Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California.
- 138 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. tracy.omara@qimrberghofer.edu.au.
- PMID: 33144283
- DOI: 10.1158/1055-9965.EPI-20-0739
Item in Clipboard
Meta-Analysis
Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers
Dylan M Glubb et al.
Cancer Epidemiol Biomarkers Prev.
2021 Jan.
Display options
Format
doi: 10.1158/1055-9965.EPI-20-0739.
Epub 2020 Nov 3.
Authors
Dylan M Glubb
1
, Deborah J Thompson
2
, Katja K H Aben
3
4
, Ahmad Alsulimani
5
, Frederic Amant
6
, Daniela Annibali
6
, John Attia
7
8
, Aurelio Barricarte
9
10
11
, Matthias W Beckmann
12
, Andrew Berchuck
13
, Marina Bermisheva
14
, Marcus Q Bernardini
15
, Katharina Bischof
16
17
, Line Bjorge
16
17
, Clara Bodelon
18
, Alison H Brand
19
20
, James D Brenton
21
, Louise A Brinton
18
, Fiona Bruinsma
22
, Daniel D Buchanan
23
24
25
26
, Stefanie Burghaus
12
, Ralf Butzow
27
, Hui Cai
28
, Michael E Carney
29
, Stephen J Chanock
30
, Chu Chen
31
, Xiao Qing Chen
1
, Zhihua Chen
32
, Linda S Cook
33
34
, Julie M Cunningham
35
, Immaculata De Vivo
36
37
, Anna deFazio
19
38
, Jennifer A Doherty
39
, Thilo Dörk
40
, Andreas du Bois
41
42
, Alison M Dunning
43
, Matthias Dürst
44
, Todd Edwards
45
, Robert P Edwards
46
47
, Arif B Ekici
48
, Ailith Ewing
2
, Peter A Fasching
12
49
, Sarah Ferguson
15
, James M Flanagan
50
, Florentia Fostira
51
, George Fountzilas
52
, Christine M Friedenreich
34
, Bo Gao
38
53
, Mia M Gaudet
54
, Jan Gawełko
55
, Aleksandra Gentry-Maharaj
56
, Graham G Giles
22
24
57
, Rosalind Glasspool
58
, Marc T Goodman
59
, Jacek Gronwald
60
, Holly R Harris
61
62
, Philipp Harter
41
, Alexander Hein
12
, Florian Heitz
41
, Michelle A T Hildebrandt
63
, Peter Hillemanns
40
, Estrid Høgdall
64
65
, Claus K Høgdall
66
, Elizabeth G Holliday
7
8
, David G Huntsman
67
68
69
70
, Tomasz Huzarski
71
72
, Anna Jakubowska
60
73
, Allan Jensen
64
, Michael E Jones
74
, Beth Y Karlan
75
, Anthony Karnezis
76
, Joseph L Kelley
47
, Elza Khusnutdinova
14
77
, Jeffrey L Killeen
78
, Susanne K Kjaer
64
79
, Rüdiger Klapdor
80
, Martin Köbel
81
, Bozena Konopka
82
, Irene Konstantopoulou
51
, Reidun K Kopperud
16
17
, Madhuri Koti
83
, Peter Kraft
37
84
, Jolanta Kupryjanczyk
82
, Diether Lambrechts
85
86
, Melissa C Larson
87
, Loic Le Marchand
88
, Shashikant Lele
89
, Jenny Lester
75
, Andrew J Li
90
, Dong Liang
91
, Clemens Liebrich
92
, Loren Lipworth
93
, Jolanta Lissowska
94
, Lingeng Lu
95
, Karen H Lu
96
, Alessandra Macciotta
97
, Amalia Mattiello
98
, Taymaa May
15
, Jessica N McAlpine
99
, Valerie McGuire
100
, Iain A McNeish
101
102
, Usha Menon
56
, Francesmary Modugno
47
103
, Kirsten B Moysich
5
, Heli Nevanlinna
104
, Kunle Odunsi
89
, Håkan Olsson
105
, Sandra Orsulic
90
, Ana Osorio
106
107
, Domenico Palli
108
, Tjoung-Won Park-Simon
40
, Celeste L Pearce
109
110
, Tanja Pejovic
111
112
, Jennifer B Permuth
113
, Agnieszka Podgorska
82
, Susan J Ramus
114
115
, Timothy R Rebbeck
116
117
, Marjorie J Riggan
13
, Harvey A Risch
95
, Joseph H Rothstein
118
119
, Ingo B Runnebaum
44
, Rodney J Scott
7
120
121
, Thomas A Sellers
113
, Janine Senz
67
68
, Veronica Wendy Setiawan
122
, Nadeem Siddiqui
123
, Weiva Sieh
118
119
, Beata Spiewankiewicz
124
, Rebecca Sutphen
125
, Anthony J Swerdlow
74
126
, Lukasz Michael Szafron
127
, Soo Hwang Teo
128
129
, Pamela J Thompson
59
, Liv Cecilie Vestrheim Thomsen
16
17
, Linda Titus
130
, Alicia Tone
15
, Rosario Tumino
131
, Constance Turman
37
, Adriaan Vanderstichele
132
, Digna Velez Edwards
133
, Ignace Vergote
132
, Robert A Vierkant
87
, Zhaoming Wang
18
, Shan Wang-Gohrke
134
, Penelope M Webb
135
; OPAL Study Group; AOCS Group; Emily White
62
136
, Alice S Whittemore
100
137
, Stacey J Winham
87
, Xifeng Wu
63
, Anna H Wu
122
, Drakoulis Yannoukakos
51
, Amanda B Spurdle
1
, Tracy A O'Mara
138
Affiliations
- 1 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 2 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 3 Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
- 4 Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.
- 5 Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
- 6 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
- 7 Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
- 8 Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
- 9 CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
- 10 Navarra Public Health Institute, Pamplona, Spain.
- 11 Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
- 12 Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
- 13 Department of Gynecologic Oncology, Duke University Hospital, Durham, North Carolina.
- 14 Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
- 15 Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.
- 16 Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
- 17 Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
- 18 Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
- 19 Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
- 20 University of Sydney, Sydney, New South Wales, Australia.
- 21 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
- 22 Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 23 Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
- 24 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 25 Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.
- 26 University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
- 27 Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 28 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
- 29 John A. Burns School of Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, Hawaii.
- 30 Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, Maryland.
- 31 Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 32 Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida.
- 33 University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico.
- 34 Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.
- 35 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
- 36 Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
- 37 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
- 38 Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
- 39 Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
- 40 Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 41 Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany.
- 42 Praxis für Humangenetik, Wiesbaden, Germany.
- 43 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
- 44 Department of Gynaecology, Jena University Hospital- Friedrich Schiller University, Jena, Germany.
- 45 Division of Epidemiology, Center for Human Genetics Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
- 46 Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
- 47 Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
- 48 Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
- 49 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California.
- 50 Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.
- 51 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos," Athens, Greece.
- 52 Second Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
- 53 The Crown Princess Mary Cancer Centre Westmead, Sydney-West Cancer Network, Westmead Hospital, Sydney, New South Wales, Australia.
- 54 Department of Population Science, American Cancer Society, Atlanta, Georgia.
- 55 Institute of Nursing and Health Sciences, Medical Faculty, University of Rzeszów, Rzeszów, Poland.
- 56 MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
- 57 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
- 58 Department of Medical Oncology, Beatson West of Scotland Cancer Centre and University of Glasgow, Glasgow, UK.
- 59 Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.
- 60 Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 61 Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 62 Department of Epidemiology, University of Washington, Seattle, Washington.
- 63 Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
- 64 Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
- 65 Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
- 66 The Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 67 British Columbia's Ovarian Cancer Research (OVCARE) Program, BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.
- 68 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
- 69 Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
- 70 Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.
- 71 Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
- 72 Department of Genetics and Pathology, University of Zielona Góra, Zielona Góra, Poland.
- 73 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
- 74 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 75 David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California.
- 76 Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California.
- 77 Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.
- 78 Department of Pathology, Kapiolani Medical Center for Women and Children, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
- 79 Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
- 80 Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
- 81 Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada.
- 82 Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
- 83 Departments of Biomedical and Molecular Sciences and Obstetrics and Gynaecology, Cancer Biology and Genetics Division, Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
- 84 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
- 85 VIB Center for Cancer Biology, Leuven, Belgium.
- 86 Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
- 87 Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
- 88 Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
- 89 Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York.
- 90 Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
- 91 College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas.
- 92 Clinics of Gynaecology, Cancer Center Wolfsburg, Wolfsburg, Germany.
- 93 Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
- 94 Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland.
- 95 Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
- 96 Department of Gynecologic Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas.
- 97 Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany.
- 98 Dipertimento Di Medicina Clinca e Chirurgia, Federico II University, Naples, Italy.
- 99 British Columbia's Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver General Hospital and BC Cancer, Vancouver, BC, Canada.
- 100 Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.
- 101 Division of Cancer and Ovarian Cancer Action Research Centre, Department Surgery and Cancer, Imperial College London, London, UK.
- 102 Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
- 103 Womens Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
- 104 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 105 Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
- 106 Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
- 107 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
- 108 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
- 109 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
- 110 Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
- 111 Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.
- 112 Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.
- 113 Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
- 114 School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, New South Wales, Australia.
- 115 Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia.
- 116 Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
- 117 Dana-Farber Cancer Institute, Boston, Massachusetts.
- 118 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
- 119 Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
- 120 Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.
- 121 Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia.
- 122 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
- 123 Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
- 124 Tytus Chałbiński Specialist Hospital in Radom, Warsaw, Poland.
- 125 Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida.
- 126 Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
- 127 Department of Immunology, the Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland.
- 128 Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
- 129 Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
- 130 Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
- 131 Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany.
- 132 Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
- 133 Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Women's Health Research, Vanderbilt University Medical Center, Nashville, Tennessee.
- 134 Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
- 135 Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 136 Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 137 Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California.
- 138 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. tracy.omara@qimrberghofer.edu.au.
- PMID: 33144283
- DOI: 10.1158/1055-9965.EPI-20-0739
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Abstract
Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers.
Methods: Using LDScore regression, we explored the genetic correlation between endometrial cancer and ovarian cancer. To identify loci associated with the risk of both cancers, we implemented a pipeline of statistical genetic analyses (i.e., inverse-variance meta-analysis, colocalization, and M-values) and performed analyses stratified by subtype. Candidate target genes were then prioritized using functional genomic data.
Results: Genetic correlation analysis revealed significant genetic correlation between the two cancers (rG = 0.43, P = 2.66 × 10-5). We found seven loci associated with risk for both cancers (P Bonferroni < 2.4 × 10-9). In addition, four novel subgenome-wide regions at 7p22.2, 7q22.1, 9p12, and 11q13.3 were identified (P < 5 × 10-7). Promoter-associated HiChIP chromatin loops from immortalized endometrium and ovarian cell lines and expression quantitative trait loci data highlighted candidate target genes for further investigation.
Conclusions: Using cross-cancer GWAS meta-analysis, we have identified several joint endometrial and ovarian cancer risk loci and candidate target genes for future functional analysis.
Impact: Our research highlights the shared genetic relationship between endometrial cancer and ovarian cancer. Further studies in larger sample sets are required to confirm our findings.
©2020 American Association for Cancer Research.
References
-
- Koshiyama M, Matsumura N, Konishi I. Recent concepts of ovarian carcinogenesis: type I and type II. Biomed Res Int. 2014;2014:934261.
-
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
-
- Cramer DW. The epidemiology of endometrial and ovarian cancer. Hematol Oncol Clin North Am. 2012;26:1–12.
-
- Braem MGM, Onland-Moret NC, van den Brandt PA, Goldbohm RA, Peeters PHM, Kruitwagen RFPM, et al. Reproductive and hormonal factors in association with ovarian cancer in the Netherlands cohort study. Am J Epidemiol. 2010;172:1181–9.
-
- Dossus L, Allen N, Kaaks R, Bakken K, Lund E, Tjonneland A, et al. Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2010;127:442–51.
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