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. 2020 Nov-Dec;34(6):3181-3186.
doi: 10.21873/invivo.12153.

Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan

Li-Hsiou Chen #  1   2 , Kuo-Liang Chiu #  2   3 , Te-Chun Hsia #  4 , Yen-Hsien Lee  2 , Te-Chun Shen  1   4 , Chia-Hsiang Li  1   4 , Yi-Cheng Shen  1   4 , Wen-Shin Chang  1   4 , Chia-Wen Tsai  1   4 , DA-Tian Bau  5   4   6
Affiliations

Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan

Li-Hsiou Chen et al. In Vivo. 2020 Nov-Dec.

Abstract

Background/aim: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese.

Materials and methods: One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes.

Results: CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053.

Conclusion: The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan.

Keywords: Asthma; MMP2; Taiwan; genotype; polymorphism; promoter.

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Conflict of interest statement

The Authors declare no conflicts of interest with regard to this study.

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