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. 2020 Nov-Dec;34(6):3181-3186.
doi: 10.21873/invivo.12153.

Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan

Li-Hsiou Chen #  1   2 , Kuo-Liang Chiu #  2   3 , Te-Chun Hsia #  4 , Yen-Hsien Lee  2 , Te-Chun Shen  1   4 , Chia-Hsiang Li  1   4 , Yi-Cheng Shen  1   4 , Wen-Shin Chang  1   4 , Chia-Wen Tsai  1   4 , DA-Tian Bau  5   4   6
Affiliations

Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan

Li-Hsiou Chen et al. In Vivo. 2020 Nov-Dec.

Abstract

Background/aim: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese.

Materials and methods: One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes.

Results: CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053.

Conclusion: The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan.

Keywords: Asthma; MMP2; Taiwan; genotype; polymorphism; promoter.

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Conflict of interest statement

The Authors declare no conflicts of interest with regard to this study.

References

    1. Holgate ST. Genetic and environmental interaction in allergy and asthma. J Allergy Clin Immunol. 1999;104(6):1139–1146. doi: 10.1016/s0091-6749(99)70005-9. - DOI - PMC - PubMed
    1. Madore AM, Perron S, Turmel V, Laviolette M, Bissonnette EY, Laprise C. Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways. Hum Immunol. 2010;71(2):144–150. doi: 10.1016/j.humimm.2009.11.005. - DOI - PMC - PubMed
    1. Steinke JW, Rich SS, Borish L. 5. Genetics of allergic disease. J Allergy Clin Immunol. 2008;121(2 Suppl):S384–387. doi: 10.1016/j.jaci.2007.07.029. quiz S416. - DOI - PubMed
    1. Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedon JC, Cookson WO, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O’Connor GT, Raby BA, Silverman EK, Weiss ST. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009;84(5):581–593. doi: 10.1016/j.ajhg.2009.04.006. - DOI - PMC - PubMed
    1. Mattiuzzi C, Lippi G. Worldwide asthma epidemiology: insights from the Global Health Data Exchange database. Int Forum Allergy Rhinol. 2020;10(1):75–80. doi: 10.1002/alr.22464. - DOI - PubMed

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