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. 2020 Nov-Dec;34(6):3367-3374.
doi: 10.21873/invivo.12175.

Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time

Hiroaki Miyake  1 , Koji Murono  2 , Kazushige Kawai  2 , Hiroaki Nozawa  2 , Harufumi Maki  3 , Kiyoshi Hasegawa  3 , Jun Nakajima  4 , Soichiro Ishihara  2
Affiliations

Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time

Hiroaki Miyake et al. In Vivo. 2020 Nov-Dec.

Abstract

Background/aim: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC).

Patients and methods: We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography.

Results: Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases.

Conclusion: Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT.

Keywords: Colorectal carcinoma; doubling time; prognosis; recurrence; tumor growth rate.

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Conflict of interest statement

There are no conflicts of interest to declare regarding this study.

Figures

Figure 1
Figure 1. Overall survival curves after metachronous a) liver, b) lung, and c) peritoneal metastases of CRC according to DT. CRC: Colorectal cancer; DT: doubling time
Figure 2
Figure 2. Overall survival curves after metachronous a) liver, b) lung, and c) peritoneal metastases of CRC according to DT and surgical resection. CRC: Colorectal cancer; DT: doubling time
See this image and copyright information in PMC

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