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Review
. 2020 Nov 3;5(1):259.
doi: 10.1038/s41392-020-00371-9.

Small is beautiful-a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

Angela M Otto  1
Affiliations
Review

Small is beautiful-a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

Angela M Otto. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
The metabolic home of a sugar-derived metabolite signaling to mTORC1. Glycolysis following uptake of glucose, fructose, and mannose proceeds to the trioses dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GAP), which are at a metabolic junction between further glycolytic reactions and lipid synthesis. Those enzymes knocked out or inhibited in the presented study (Orozco et al.) are highlighted. HK hexokinase; GPI glucose-6-phosphate isomerase; PFK phosphofructokinase; TPI triose phosphate isomerase; GDP glycerol-3-phosphate dehydrogenase; GAPDH glyceraldehyde-3-phophate dehydrogenase. Dashed lines indicate that several steps are involved; in the case of mTORC1 these are yet unknown
See this image and copyright information in PMC

References

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