Intrinsic brain activity associated with eye gaze during mother-child interaction

Abstract

Mother-child interactions impact child social development and psychological health. This study focused on eye-gaze interactions, especially eye contact as synchronized gaze, which is an important non-verbal communication tool in human interactions. We performed brain-image analysis of mothers and children using resting-state functional magnetic resonance imaging and quantitatively evaluated the quality of mother-child interactions using the Interaction Rating Scale to investigate how it is related to the frequency of mother-child eye contact. As a result, we found a positive correlation between the frequency of eye gaze and the right anterior insula (AI) or middle frontal gyrus in children and a positive correlation with the anterior cingulate cortex (ACC) and precuneus/cuneus in mothers. Especially, when eye contact was made, the association with the right AI in children and ACC in mothers was retained, suggesting the involvement of the salience network responsible for modulating internal and external cognition. In addition, the frequency of eye contact was positively associated with the quality of mother-child interaction. These results suggest that the salience network is a major candidate for the neural basis involved in maintaining efficient eye contact and that it plays an important role in establishing positive mother-child interactions.

Figure 1

Brain regions in children showing positive correlations (A) and negative correlations (B)in the eye-gaze conditionand positive correlations (C) and negative correlations (D) in the eye-contact condition. The statistical threshold for the contrasts was cluster-level P < 0.05 family-wise error corrected for multiple comparisons and voxel-level P < 0.005 uncorrected for height. The color bar denotes the t-statistic range. The dashed line represents each functional area (DMN, SN and CEN) of the resting network found in previous studies^–. AI: anterior insula, MFG: medial frontal gyrus, SPL: superior parietal lobule, DMN: default mode network, SN: salience network, CEN: central executive network.

Figure 2

Brain regions in mothers showing positive correlations (A) and negative correlations (B) in the eye-gaze condition and positive correlations (C) and negative correlations (D) in the eye-contact condition. The statistical threshold for the contrasts was cluster-level P < 0.05 family-wise error corrected for multiple comparisons and voxel-level P < 0.005 uncorrected for height. The color bar denotes the t-statistic range. The dashed line represents each functional area (DMN, SN and CEN) of the resting network found in previous studies^–. ACC: anterior cingulate cortex, AG: angular gyrus, Cu: cuneus, MTG: middle temporal gyrus, PCu: precuneus, PG: paracentral gyrus, DMN: default mode network, SN: salience network, CEN: central executive network.