Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Dec;20(12):718-719.
doi: 10.1038/s41577-020-00475-x.

A deadly fibroblast response to flu

Yvonne Bordon  1
Affiliations
Comment

A deadly fibroblast response to flu

Yvonne Bordon. Nat Rev Immunol. 2020 Dec.

Abstract

Upregulation of the protease ADAMTS4 by activated fibroblasts drives immunopathology in the lungs and respiratory failure during severe viral infections.

PubMed Disclaimer

Figures

None
Science Photo Library/Alamy Stock Photo
See this image and copyright information in PMC

Comment on

  • Exuberant fibroblast activity compromises lung function via ADAMTS4.
    Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM; PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators; Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Boyd DF, et al. Nature. 2020 Nov;587(7834):466-471. doi: 10.1038/s41586-020-2877-5. Epub 2020 Oct 28. Nature. 2020. PMID: 33116313 Free PMC article.

References

    1. Boyd DF, et al. Exuberant fibroblast activity compromises lung function via ADAMTS4. Nature. 2020 doi: 10.1038/s41586-020-2877-5. - DOI - PMC - PubMed