Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Oct 21:2020:8871951.
doi: 10.1155/2020/8871951. eCollection 2020.

The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy

Chuyu Li #  1   2   3 , Jing Zhou #  1   2   3 , Zengshu Huang  1   2   3 , Xinyao Pan  1   2   3 , Wingting Leung  1   2   3 , Lijia Chen  1   2   3 , Yanzhi Zhang  1   2   3 , Lan Wang  1   2   3 , Yizhen Sima  1   2   3 , Hans-Jürgen Gober  4 , Na Zhang  1   2   3 , Xuemin Qiu  1   2   3 , Lisha Li  1   2   3 , Liang Guan  5   6 , Ling Wang  1   2   3
Affiliations
Review

The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy

Chuyu Li et al. Dis Markers. .

Abstract

Antithyroid antibodies, which include thyroid-stimulating hormone receptor antibodies (TRAbs), thyroid peroxidase antibodies (TPOAbs), and thyroid globulin antibodies (TgAbs), are widely known for their tight association with thyroid autoimmune diseases. The variation in all three kinds of antibodies also showed different trends during and after pregnancy (Weetman, 2010). This article reviewed the the physiological changes, while focusing on the variation of thyroid antibodies concentration in women during and after pregnancy, and adverse consequences related to their elevation. Since abnormal elevations of these antithyroid antibodies may lead to adverse outcomes in both mothers and fetuses, special attention must be paid to the titer of the antibodies during pregnancy. The molecular mechanisms of the variations in those antibodies have yet to be explained. The frequency and timing of thyroid antibody measurement, as well as different reference levels, also remain to be elucidated.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
The variation in TSH before, during, and after pregnancy. The curve is a set of data from one patient at Ruijin Hospital. The delivery date of her infant was December 1, 2017. The last menstrual period was February 27, 2017, according to the gestational weeks and delivery date. The TSH level dropped to the lowest level at the end of the first trimester and then gradually ascended. T: trimester.
Figure 2
Figure 2
The variation in TPOAbs before, during, and after pregnancy. The curve is a set of data from one patient at Ruijin Hospital. The patient suffered from Hashimoto's thyroiditis, and the delivery date of her infant was July 2, 2018. The last menstrual period was November 6, 2017, according to the gestational weeks and delivery date. TPOAb levels decreased during pregnancy and rebounded after delivery. T: trimester.
Figure 3
Figure 3
The variation in TgAbs before, during, and after pregnancy. The curve is a set of data from one patient at Ruijin Hospital. The delivery date of her infant was July 12, 2017. The last menstrual period was October 10, 2016, according to the gestational weeks and delivery date. The TgAb level decreased during pregnancy and rebounded after delivery. T: trimester.
See this image and copyright information in PMC

References

    1. Moulton V. R. Sex hormones in acquired immunity and autoimmune disease. Frontiers in Immunology. 2018;9:p. 2279. doi: 10.3389/fimmu.2018.02279. - DOI - PMC - PubMed
    1. Zhang Y. W., Tong N. W. The interpretation of the newest guideline of thyroid dysfunction in pregnancy. Journal of practical obstetrics and gynecology. 2015;31(12):899–902.
    1. Kahaly G. J., Bartalena L., Hegedüs L., Leenhardt L., Poppe K., Pearce S. H. 2018 European Thyroid Association guideline for the management of graves' hyperthyroidism. European Thyroid Journal. 2018;7(4):167–186. doi: 10.1159/000490384. - DOI - PMC - PubMed
    1. Ross D. S., Burch H. B., Cooper D. S., et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26(10):1343–1421. doi: 10.1089/thy.2016.0229. - DOI - PubMed
    1. Chinese Society of Endocrinology. Guidelines for the diagnosis and treatment of hypothyroidism in adults. Chinese Journal of Endocrinology and Metabolism. 2017;33(2):167–180.